3-甲氧基-2-硝基苯甲酸合成路线 （共 46 条）
参考文献
Froelicher; Cohen
Journal of the Chemical Society, 1921 , vol. 119, p. 1431
参考文献
Ewins
Journal of the Chemical Society, 1912 , vol. 101, p. 548
参考文献
Cain; Simonsen
Journal of the Chemical Society, 1914 , vol. 105, p. 163
反应条件
1: diphenyl phosphoryl azide; triethylamine / 10 h / Reflux 2: trifluoroacetic acid / dichloromethane / 4 h / 20 °C 3: palladium 10 on activated carbon; hydrogen; acetic acid / ethanol; ethyl acetate / 11 h / 20 °C / 760.05 Torr View Scheme
参考文献
Ochiai, Koji; Takita, Satoshi; Eiraku, Tomohiko; Kojima, Akihiko; Iwase, Kazuhiko; Kishi, Tetsuya; Fukuchi, Kazunori; Yasue, Tokutaro; Adams, David R.; Allcock, Robert W.; Jiang, Zhong; Kohno, Yasushi
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 5 p. 1644 - 1658
反应条件
hydrogen; palladium on activated charcoal in ethanol P=2625.2 Torr; 0.166667 h; Ambient temperature;
参考文献
Ife, Robert J.; Brown, Thomas H.; Blurton, Peter; Keeling, David J.; Leach, Colin A.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 14 p. 2763 - 2773
反应条件
1.1: thionyl chloride / 3 h / 75 °C 2.1: diethyl ether; ethanol / 20 °C / Reflux 2.2: 18 h / Reflux 3.1: zinc; acetic acid / tetrahydrofuran / 4 h / 0 - 20 °C View Scheme
参考文献
H. LUNDBECK A/S; KEHLER, Jan; KILBURN, John Paul; NIELSEN, Jacob; PÜSCHL, Ask; LANGGÅRD, Morten; JESSING, Mikkel; MARIGO, Mauro
Patent: WO2013/50527 A1, 2013 ;
反应条件
1: SOCl2 2: 1.) NaN3, 2.) H2O, 4.) NaOH, 5.) HCl 3: 1.) NaNO2, HCl, 2.) NaSbF6, 3.) SiO2 4: H2 / 10percent Pd/C / ethyl acetate / 1 h / 760 Torr View Scheme
参考文献
Kimura; Watanabe; Matsui; Hayashi; Tanaka; Ohtsuka; Saeki; Kogushi; Kabayashi; Akasaka; Yamagishi; Saitou; Yamatsu
Journal of Medicinal Chemistry, 1993 , vol. 36, # 11 p. 1641 - 1653
反应条件
1: thionyl chloride 3: dioxane; Ag2O; aqueous Na2CO3 / weiteres Reagens: wss. Na2S2O3 View Scheme
参考文献
Blair; Newbold
Journal of the Chemical Society, 1955 , p. 2871,2873
反应条件
ammonium hydroxide; thionyl chloride in tetrahydrofuran
参考文献
Pfizer Inc.
Patent: US5482941 A1, 1996 ;
US 5482941 A
反应条件
1: 97 percent / H2, aq. NaHCO3 / Pd/C 2: K2CO3, Cu, CuBr, N-methylpyrrolidinone / 2-ethoxy-ethanol / 2 h / 150 °C 3: H2SO4 / 4 h / 90 °C View Scheme
参考文献
Denny; Atwell; Baguley
Journal of Medicinal Chemistry, 1984 , vol. 27, # 3 p. 363 - 367
