4-羟基-3,5-二甲基苯甲酸合成路线 （共 30 条）
反应条件
1: 4-iodo-2,6-dimethyl-phenol With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.333333 h; 2: carbon dioxide in tetrahydrofuran; hexane T=-78°C; 0.5 h;
参考文献
Lu, Yixin; Lum, Tze Keong; Augustine, Yoon Wui Leow; Weltrowska, Grazyna; Nguyen, Thi M.-D.; Lemieux, Carole; Chung, Nga N.; Schiller, Peter W.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 17 p. 5382 - 5385
反应条件
pyridine hydrochloride T=200°C; 0.5 h; Microwave irradiationIonic liquid;
参考文献
Cheng, Lili; Aw, Carlin; Ong, Siew Siang; Lu, Yixin
Bulletin of the Chemical Society of Japan, 2007 , vol. 80, # 10 p. 2008 - 2010
反应条件
tetrabutylammomium bromide; hydrogen bromide in dichloromethane 24 h; Heating;
参考文献
Bhalerao; Raju; Neelakantan
Synthetic Communications, 1995 , vol. 25, # 10 p. 1433 - 1439
反应条件
water; potassium carbonate T=100°C; 24 h;
参考文献
Wittmann, Sebastian; Schaetz, Alexander; Grass, Robert N.; Stark, Wendelin J.; Reiser, Oliver
Angewandte Chemie - International Edition, 2010 , vol. 49, # 10 p. 1867 - 1870
参考文献
Newman; Gildenhorn
Journal of the American Chemical Society, 1948 , vol. 70, p. 317
反应条件
1.1: 30 percent / aq. HCl; KI; KIO3 / methanol / 2 h / cooling 2.1: n-BuLi / tetrahydrofuran; hexane / 0.33 h / -78 °C 2.2: 41 percent / tetrahydrofuran; hexane / 0.5 h / -78 °C View Scheme
参考文献
Lu, Yixin; Lum, Tze Keong; Augustine, Yoon Wui Leow; Weltrowska, Grazyna; Nguyen, Thi M.-D.; Lemieux, Carole; Chung, Nga N.; Schiller, Peter W.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 17 p. 5382 - 5385
反应条件
1: sulfuric acid; chloroform; sodium azide 2: copper (II)-sulfate / Diazotization View Scheme
参考文献
Newman; Gildenhorn
Journal of the American Chemical Society, 1948 , vol. 70, p. 317
反应条件
1: 2-hydroxy-1,3-dimethylbenzene With sodium hydride 2: carbon dioxide Kolbe-Schmidt reaction;
参考文献
Wessig, Pablo; Teubner, Janek
Synlett, 2006 , # 10 p. 1543 - 1546
反应条件
water; sodium hydroxide in methanol 0.0833333 h; Reflux;
参考文献
Khan, Sadia; Fatima, Itrat; Hussain Kazmi, Mehdi; Malik, Abdul
Helvetica Chimica Acta, 2013 , vol. 96, # 6 p. 1176 - 1181
反应条件
sodium hydroxide; silver(l) oxide
参考文献
Thiele; Eichwede
Justus Liebigs Annalen der Chemie, 1900 , vol. 311, p. 366 Anm.
