1: 1,3-dihydro-1,3-dioxo-2H-isoindole-2-acetic acid With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane
T=20°C; 4 h;
2: benzylamine With triethylamine in dichloromethane
0.5 h;
参考文献
JANSSEN PHARMACEUTICA N.V.
Patent: WO2007/50612 A1, 2007 ;
Location in patent: Page/Page column 98-99 ;
WO 2007/050612 A1
1: 1,3-dihydro-1,3-dioxo-2H-isoindole-2-acetic acid With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane
T=20°C; 4 h;
2: benzylamine With triethylamine in dichloromethane
