2,4,5-三甲氧基苯甲酸合成路线 （共 59 条）
反应条件
1: With palladium (II) trifluoroacetate; 6-mbipy in water
T=130°C; 1 h; Microwave irradiation;
2: With formic acid in water
T=100°C; 1 h;
参考文献
Lindh, Jonas; Sjoeberg, Per J. R.; Larhed, Mats
Angewandte Chemie - International Edition, 2010 , vol. 49, # 42 p. 7733 - 7737
反应条件
nitric acid in acetic acid
T=10 - 15°C; 1 h;
参考文献
Cotelle, Philippe; Catteau, Jeanpierre
Synthetic Communications, 1996 , vol. 26, # 22 p. 4105 - 4112
参考文献
Fabinyi; Szeki
Chemische Berichte, 1906 , vol. 39, p. 3684
反应条件
boron tribromide
1.) CH2Cl2; Yield given. Multistep reaction;
参考文献
Kelly, T. Ross; Jagoe, Christopher T.; Li, Qun
Journal of the American Chemical Society, 1989 , vol. 111, # 12 p. 4522 - 4524
反应条件
1: BCl3 / CH2Cl2
2: 79 percent / H2SO4 / Heating
View Scheme
参考文献
Rama Rao; Yadav; Kishta Reddy; Upender, Velaparthi
Tetrahedron Letters, 1991 , vol. 32, # 38 p. 5199 - 5202
反应条件
4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane
T=20°C;
参考文献
Bennett, Christopher J.; Caldwell, Stuart T.; McPhail, Donald B.; Morrice, Philip C.; Duthie, Garry G.; Hartley, Richard C.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 9 p. 2079 - 2098
反应条件
1: SOCl2
2: DMAP; pyridine
View Scheme
参考文献
Nakamura, Hiroyuki; Sasaki, Yusuke; Uno, Masaharu; Yoshikawa, Tomohiro; Asano, Toru; Ban, Hyun Seung; Fukazawa, Hidesuke; Shibuya, Masabumi; Uehara, Yoshimasa
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 19 p. 5127 - 5131
反应条件
1: SOCl2
2: DMAP; pyridine
View Scheme
参考文献
Nakamura, Hiroyuki; Sasaki, Yusuke; Uno, Masaharu; Yoshikawa, Tomohiro; Asano, Toru; Ban, Hyun Seung; Fukazawa, Hidesuke; Shibuya, Masabumi; Uehara, Yoshimasa
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 19 p. 5127 - 5131
反应条件
1: 1.) BBr3 / 1.) CH2Cl2
2: 48 percent / KF / dimethylformamide / 75 °C
3: 1.) aq. Na2S2O4, 2.) conc. H2SO4 / 2.) 20 -> 60 deg C
4: 70 percent / NaN(TMS)2 / tetrahydrofuran / 20 °C
5: 65 percent / NaHCO3 / Pd(OAc)2 / various solvent(s) / 15 h / 95 °C
6: 36 percent / CH2Cl2 / 4 h / Irradiation
View Scheme
参考文献
Rama Rao; Yadav; Kishta Reddy; Upender, Velaparthi
Tetrahedron Letters, 1991 , vol. 32, # 38 p. 5199 - 5202
反应条件
2: selective mono-demethylation
3: K2CO3 / dimethylformamide
4: aq. Na2S2O4
5: K2CO3 / acetone / 6 h / Heating
6: aq. KOH / ethanol / 10 h / 25 °C
7: PPE / CHCl3 / 36 h / 25 °C
8: aq. KOH / ethanol / 8 h / 25 °C
10: PCC / CH2Cl2 / 15 h / 25 °C
11: 82 percent / K2CO3 / methanol / 36 h / 25 °C
12: 95 percent / ceric ammonium nitrate / acetonitrile; H2O
13: 85 percent / Et3N*BCl3 / CH2Cl2 / 0.25 h / 0 °C
14: NaBH4
View Scheme
参考文献
Rama Rao; Yadav; Kishta Reddy; Upender, Velaparthi
Tetrahedron Letters, 1991 , vol. 32, # 38 p. 5199 - 5202
