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63148-62-9
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碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
表儿茶素
合成路线
（共 130 条）
87292-49-7
→
反应条件
490-46-0
表儿茶素
反应条件
5 Pd(OH)2/C; hydrogen in tetrahydrofuran; methanol; water T=20°C; 0.5 h;
参考文献
Ohmori, Ken; Yano, Takahisa; Suzuki, Keisuke
Organic and Biomolecular Chemistry, 2010 , vol. 8, # 12 p. 2693 - 2696
→
反应条件
213007-61-5
+
490-46-0
表儿茶素
反应条件
hydrogenchloride in methanol T=40°C; 0.5 h;
参考文献
KIRIN BEER KABUSHIKI KAISHA
Patent: EP1676572 A1, 2006 ;
Location in patent: Page/Page column 25-27; 28-29; 64 ;
29106-51-2
原花青素B4
+
989-51-5
(-)-表没食子儿茶素没食子酸酯
→
反应条件
126786-48-9
+
490-46-0
表儿茶素
反应条件
citric acid in water T=100°C; 2 h;
参考文献
Nagasaki University; Usaien Pharmaceutical Co., Ltd.; AMINO UP CHEMICAL CO. LTD.
Patent: EP1852430 A1, 2007 ;
Location in patent: Page/Page column 9-10 ;
213007-61-5
→
反应条件
490-46-0
表儿茶素
反应条件
acetic acid; nickel in ethanol T=50°C; 0.5 h;
参考文献
Lou, Hongxiang; Yuan, Huiqing; Ma, Bin; Ren, Dongmei; Ji, Mei; Oka, Syuichi
Phytochemistry, 2004 , vol. 65, # 16 p. 2391 - 2399
154-23-4
儿茶素
→
反应条件
35323-91-2
(+)-表儿茶素
+
490-46-0
表儿茶素
反应条件
CHIRAL PAK.(R). IC (250 X 4.6) mm, 5μ column in methanol T=25°C; Resolution of racemate; Product distribution / selectivity;
参考文献
SPHAERA PHARMA PTE. LTD.; Dugar, Sundeep; Mahajan, Dinesh; Giannousis, Pantelis Peter; Singh, Vijay; Kapoor, Kamal Kishore
Patent: US2014/31421 A1, 2014 ;
Location in patent: Paragraph 0212; 0213; 0214; 0215 ;
1257-08-5
(-)-表儿茶素没食子酸酯
→
反应条件
反应条件
Diaporthe sp in methanol T=27°C; 24 h;
参考文献
Agusta, Andria; Maehara, Shoji; Ohashi, Kazuyoshi; Simanjuntak, Partomuan; Shibuya, Hirotaka
Chemical and Pharmaceutical Bulletin, 2005 , vol. 53, # 12 p. 1565 - 1569
117-39-5
槲皮素
→
反应条件
490-46-0
表儿茶素
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 15 h / 20 - 70 °C 1.2: 1 h / 20 °C 2.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran / 4 h / 0 - 5 °C / Inert atmosphere 2.2: Inert atmosphere; Cooling 3.1: hydrogen / palladium 10 on activated carbon / ethyl acetate; methanol / 5 h / 50 °C / Inert atmosphere 4.1: potassium carbonate / N,N-dimethyl-formamide / 20 h / 20 °C 4.2: 20 °C 5.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 6 h / 20 - 40 °C / Inert atmosphere 6.1: potassium carbonate / dichloromethane; methanol / 30 h / 20 °C 7.1: hydrogen / palladium(II) oxide hydrate / ethyl acetate / 40 h / 20 °C View Scheme
参考文献
SPHAERA PHARMA PVT. LTD; DUGAR, Sundeep; MAHAJAN, Dinesh; GIANNOUSIS, Pantelis, Peter; SINGH, Vijay; KAPOOR, Kamal Kishore
Patent: WO2012/101652 A2, 2012 ;
13157-90-9
苄奎辛
→
反应条件
490-46-0
表儿茶素
反应条件
1.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran / 4 h / 0 - 5 °C / Inert atmosphere 1.2: Inert atmosphere; Cooling 2.1: hydrogen / palladium 10 on activated carbon / ethyl acetate; methanol / 5 h / 50 °C / Inert atmosphere 3.1: potassium carbonate / N,N-dimethyl-formamide / 20 h / 20 °C 3.2: 20 °C 4.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 6 h / 20 - 40 °C / Inert atmosphere 5.1: potassium carbonate / dichloromethane; methanol / 30 h / 20 °C 6.1: hydrogen / palladium(II) oxide hydrate / ethyl acetate / 40 h / 20 °C View Scheme
参考文献
SPHAERA PHARMA PVT. LTD; DUGAR, Sundeep; MAHAJAN, Dinesh; GIANNOUSIS, Pantelis, Peter; SINGH, Vijay; KAPOOR, Kamal Kishore
Patent: WO2012/101652 A2, 2012 ;
1392190-80-5
→
反应条件
490-46-0
表儿茶素
反应条件
1.1: hydrogen / palladium 10 on activated carbon / ethyl acetate; methanol / 5 h / 50 °C / Inert atmosphere 2.1: potassium carbonate / N,N-dimethyl-formamide / 20 h / 20 °C 2.2: 20 °C 3.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 6 h / 20 - 40 °C / Inert atmosphere 4.1: potassium carbonate / dichloromethane; methanol / 30 h / 20 °C 5.1: hydrogen / palladium(II) oxide hydrate / ethyl acetate / 40 h / 20 °C View Scheme
参考文献
SPHAERA PHARMA PVT. LTD; DUGAR, Sundeep; MAHAJAN, Dinesh; GIANNOUSIS, Pantelis, Peter; SINGH, Vijay; KAPOOR, Kamal Kishore
Patent: WO2012/101652 A2, 2012 ;
117-39-5
槲皮素
→
反应条件
35323-91-2
(+)-表儿茶素
+
490-46-0
表儿茶素
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 15 h / 20 - 70 °C 1.2: 1 h / 20 °C 2.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran / 4 h / 0 - 5 °C / Inert atmosphere 2.2: Inert atmosphere; Cooling 3.1: hydrogen / palladium 10 on activated carbon / ethyl acetate; methanol / 5 h / 50 °C / Inert atmosphere 4.1: CHIRAL PAK.(R). IC (250 X 4.6) mm, 5μ column / methanol / 25 °C / Resolution of racemate View Scheme
参考文献
SPHAERA PHARMA PVT. LTD; DUGAR, Sundeep; MAHAJAN, Dinesh; GIANNOUSIS, Pantelis, Peter; SINGH, Vijay; KAPOOR, Kamal Kishore
Patent: WO2012/101652 A2, 2012 ;
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