(1a,2a,3b,4b)-2,4-二(4-羟基苯基)-1,3-环丁烷二甲酸合成路线 (共 1 条)
反应条件
1: 95 percent / 2M NaOH / 4 h / 80 °C
2: 92 percent / SOCl2, pyridine / benzene / 1 h / Heating
3: 87 percent / benzene; diethyl ether
4: 69 percent / silver benzoate, (C2H5)3N / 1.) 24 h, 2.) reflux, 0.5 h
5: 96 percent / methanolic NaOH
6: 82 percent / polyphosphoric acid / 0.58 h / 70 °C
7: 1.) Raney Ni, 2.) H2 / 2.) Pd/C / 1.) ethyl acetate, reflux, 15 min, 2.) acetic acid, 70 deg C, 4 h, 50 psi
8: 55 percent / BBr3 / CH2Cl2 / 12 h
View Scheme
参考文献
Ruehle; Browne; Vickery; Beller; Eisenbraun; Loghry; Van der Helm
Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1410 - 1414