3,5-二苯基-2-异恶唑啉合成路线 （共 45 条）
反应条件
sodium hydroxide; hydroxylamine hydrochloride; barium dihydroxide in ethanol
2 h; Heating;
参考文献
Sinisterra, J. V.; Marinas, J. M.
Bulletin des Societes Chimiques Belges, 1987 , vol. 96, # 4 p. 293 - 302
反应条件
tert-butylhypochlorite in dichloromethane
5 h; Ambient temperature;
参考文献
Moriya, Osamu; Takenaka, Hideo; Urata, Yoshikiyo; Endo, Takeshi
Journal of the Chemical Society, Chemical Communications, 1991 , # 23 p. 1671 - 1672
反应条件
hydrogenchloride; methanol; potassium hydroxide; hydroxylamine
参考文献
Barnes et al.
Journal of the American Chemical Society, 1954 , vol. 76, p. 276
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v. Auwers; Mueller
Journal fuer Praktische Chemie (Leipzig), 1933 , vol. <2> 137, p. 102,128
反应条件
triethylamine in tetrahydrofuran
Ambient temperature;
参考文献
Davies, Christopher D.; Marsden, Stephen P.; Stokes, Elaine S. E.
Tetrahedron Letters, 1998 , vol. 39, # 46 p. 8513 - 8516
反应条件
1: 91 percent / BuLi / hexane; dimethylsulfoxide; tetrahydrofuran / 12 h / 20 °C
2: 97 percent / Jones' reagent / acetone / 12 h / 0 °C
3: 74 percent / KOH; NH2OH*HCl / methanol / 12 h / Heating
View Scheme
参考文献
Chen; Lam, Yulin; Lai, Yee-Hing
Organic Letters, 2003 , vol. 5, # 7 p. 1067 - 1069
反应条件
1: 95 percent / Bu4NI; KI / dimethylformamide / 12 h / 20 °C
2: 91 percent / BuLi / hexane; dimethylsulfoxide; tetrahydrofuran / 12 h / 20 °C
3: 97 percent / Jones' reagent / acetone / 12 h / 0 °C
4: 74 percent / KOH; NH2OH*HCl / methanol / 12 h / Heating
View Scheme
参考文献
Chen; Lam, Yulin; Lai, Yee-Hing
Organic Letters, 2003 , vol. 5, # 7 p. 1067 - 1069
反应条件
1: 97 percent / Jones' reagent / acetone / 12 h / 0 °C
2: 74 percent / KOH; NH2OH*HCl / methanol / 12 h / Heating
View Scheme
参考文献
Chen; Lam, Yulin; Lai, Yee-Hing
Organic Letters, 2003 , vol. 5, # 7 p. 1067 - 1069
反应条件
1: 72 percent / NaH / tetrahydrofuran / 0.25 h / 0 °C
2: NEt3 / CH2Cl2 / 1 h / -40 - 0 °C
3: 88 percent / CH2Cl2 / 5 h / 20 °C
View Scheme
参考文献
Muri, Dieter; Bode, Jeffrey W.; Carreira, Erick M.
Organic Letters, 2000 , vol. 2, # 4 p. 539 - 541
反应条件
1: NEt3 / CH2Cl2 / 1 h / -40 - 0 °C
2: 88 percent / CH2Cl2 / 5 h / 20 °C
View Scheme
参考文献
Muri, Dieter; Bode, Jeffrey W.; Carreira, Erick M.
Organic Letters, 2000 , vol. 2, # 4 p. 539 - 541
反应条件
1: hydroxylamine hydrochloride; pyridine / dichloromethane / 20 h / 20 °C / |Inert atmosphere
2: hexafluoroisopropyl alcohol; Oxonereg;; 3,5-dimethylphenyl iodide / methanol; water / 24 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
Yoshimura, Akira; Middleton, Kyle R.; Todora, Anthony D.; Kastern, Brent J.; Koski, Steven R.; Maskaev, Andrey V.; Zhdankin, Viktor V.
Organic Letters, 2013 , vol. 15, # 15 p. 4010 - 4013
