2-(4-乙基-2,3-二氧代-哌嗪-1-基)乙酸合成路线 （共 2 条）
反应条件
potassium carbonate in tert-butyl alcohol
参考文献
Gailunas, Andrea; Tucker, John A.; TenBrink, Ruth; Mickelson, John
Patent: US2003/109559 A1, 2003 ;
US 20030109559 A1
反应条件
1: 1-ethyl-2,3-dioxo-piperazine With potassium carbonate in butan-1-ol
T=0°C;
2: bromoacetic acid tert-butyl ester in butan-1-ol
T=20°C;
3: With trifluoroacetic acid in butan-1-ol
T=20°C; 2 h;
参考文献
ELAN PHARMACEUTICALS INC; PHARMACIA & UPJOHN COMPANY
Patent: JP2005/504737 A, 2005 ;
Location in patent: Page/Page column 129 ;
