1-甲基-3-(甲硫基)苯合成路线 （共 23 条）
反应条件
in tetrahydrofuran; diethyl ether T=-30 - 20°C; 0.05 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/9086 A1, 2004 ;
Location in patent: Page/Page column 45 ;
WO 2004/009086 A1
反应条件
1: 1-bromo-3-methylsulphanyl-benzene With n-butyllithium in diethyl ether; hexane T=0°C; 2 h; 2: methyl iodide in diethyl ether; hexane T=0 - 20°C; Further stages.;
参考文献
Cabiddu, Maria G.; Cabiddu, Salvatore; Cadoni, Enzo; De Montis, Stefania; Fattuoni, Claudia; Melis, Stefana
Tetrahedron, 2004 , vol. 60, # 17 p. 3915 - 3920
反应条件
ZnF2; copper(I) bromide T=150°C; 36 h; Sealed tubeUnder air;
参考文献
Luo, Fang; Pan, Changduo; Li, Liping; Chen, Fan; Cheng, Jiang
Chemical Communications, 2011 , vol. 47, # 18 p. 5304 - 5306
反应条件
in methanol T=0 - 5°C; Dimerization; methylthiodediazoniation;
参考文献
Barbero, Margherita; Degani, Iacopo; Diulgheroff, Nicola; Dughera, Stefano; Fochi, Rita; Migliaccio, Mara
Journal of Organic Chemistry, 2000 , vol. 65, # 18 p. 5600 - 5608
反应条件
sodium hydroxide Erwaermen auf dem Dampfbad;
参考文献
Chazin, Walter J.; Colebrook, Lawrence D.
Magnetic Resonance in Chemistry, 1985 , vol. 23, # 7 p. 597 - 604
反应条件
1: 3-methylbenzenethiol With sodium hydroxide in ethanol T=20°C; 2 h; 2: methyl halide in ethanol T=20°C; 12 h;
参考文献
Tanimoto, Shigeo; Oida, Tatsuo; Ikehira, Hideyuki; Okano, Masaya
Bulletin of the Chemical Society of Japan, 1982 , vol. 55, # 6 p. 1977 - 1978
反应条件
1: 3-methylbenzenethiol With sodium hydroxide in ethanol 0.5 h; 2: methyl iodide in ethanol T=20°C; 3 h;
参考文献
Hendriks, Christine M. M.; Lamers, Philip; Engel, Julien; Bolm, Carsten
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 17 p. 3363 - 3368
反应条件
tris(2,2'-bipyridine)chromium(III) in acetonitrile T=24.9°C; Irradiationother reag.; Rate constant;
参考文献
Gnanaraj; Rajagopal; Srinivasan
Tetrahedron, 1994 , vol. 50, # 31 p. 9447 - 9456
反应条件
in tetrachloromethane
参考文献
Vowinkel,E.
Synthesis, 1974 , p. 430 - 432
反应条件
n-butyllithium 1.) THF, -10 deg C to -5 deg C, 30 min, 2.) THF, from -10 deg C to RT, 5 h; Yield given. Multistep reaction;
参考文献
Tanimoto, Shigeo; Oida, Tatsuo; Ikehira, Hideyuki; Okano, Masaya
Bulletin of the Chemical Society of Japan, 1982 , vol. 55, # 6 p. 1977 - 1978
