1-苄基-N,N-二甲基哌啶-4-胺双盐酸盐合成路线 （共 3 条）
反应条件
hydrogen; palladium 10 on activated carbon in water; isopropyl alcohol T=20°C; 22 h;
参考文献
AMGEN INC.
Patent: WO2006/44823 A2, 2006 ;
Location in patent: Page/Page column 147-148 ;
WO 2006/044823 A2
反应条件
1: With acetic acid in 1,2-dichloro-ethane
T=0°C;
2: With sodium tris(acetoxy)borohydride in 1,2-dichloro-ethane
T=0 - 20°C; 5.8 h;
参考文献
Eisai Co., Ltd.
Patent: US2005/277652 A1, 2005 ;
Location in patent: Page/Page column 120-121 ;
US 20050277652 A1
反应条件
1: With sodium cyanoborohydride; acetic acid in methanol; water
T=0 - 20°C; 60.25 h;
2: With hydrogenchloride in 1,4-dioxane; diethyl ether
T=0°C;
参考文献
AMGEN INC.
Patent: WO2006/44823 A2, 2006 ;
Location in patent: Page/Page column 147 ;
WO 2006/044823 A2
