2-氨基-3-(2-氧代-1,2-二氢喹啉-4-基)丙酸盐酸盐合成路线 (共 4 条)
反应条件
hydrogenchloride 9 h; Heating;
参考文献
Uchida; Tabusa; Komatsu; Morita; Kanbe; Nakagawa
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 9 p. 3775 - 3786
反应条件
1: 69 percent / sodium / ethanol / 2 h 2: 89 percent / 20 percent hydrochloric acid / 9 h / Heating View Scheme
参考文献
Uchida; Tabusa; Komatsu; Morita; Kanbe; Nakagawa
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 9 p. 3775 - 3786
反应条件
1: 2-amino-3-[6-bromo-2(1H)-quinolon-4-yl]propionic acid; 2-amino-3-lt;2-(1H)-quinolinon-4-ylgt;propionic acid hydrochloride With sodium hydroxide; hydrogen; Raney nikel in water T=20°C; 2 h; 2: 4-chloro-benzoyl chloride With sodium hydroxide in water; acetone T=0°C; 3: With hydrogenchloride in water; acetone
参考文献
OTSUKA PHARMACEUTICAL CO., LTD.
Patent: WO2006/59781 A1, 2006 ;
Location in patent: Page/Page column 11-12 ;
反应条件
potassium carbonate in water; acetone 2 h;
参考文献
Uchida; Tabusa; Komatsu; Morita; Kanbe; Nakagawa
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 9 p. 3775 - 3786