2,4-二羟基-6-甲基苯甲醛合成路线 （共 25 条）
反应条件
1: 80 percent / NaClO2; aq. NaH2PO4 / dimethylsulfoxide / 12 h / 0 - 25 °C 2: 90 percent / K2CO3 / acetone / 24 h / 25 °C View Scheme
参考文献
Nicolaou; Mitchell, Helen J.; Suzuki, Hideo; Rodriguez, Rosa Maria; Baudoin, Olivier; Fylaktakidou, Konstantina C.
Angewandte Chemie - International Edition, 1999 , vol. 38, # 22 p. 3334 - 3339
反应条件
1.1: pyridinium p-toluenesulfonate / dichloromethane / 18 h / 20 °C
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / Cooling with ice
2.2: 1 h / 20 °C
3.1: methanol / Amberlyst.(R). 15 / 1 h / 50 °C
View Scheme
参考文献
ANACOR PHARMACEUTICALS, INC.; GLAXOSMITHKINE LLC; XIA, Yi; ALLEY, Michael, Richard Kevin; ZHOU, Yasheen; SINGH, Rajeshwar; DING, Charles; CAO, Kathy; PLATTNER, Jacob, J.; OU, Ligong; JIA, Guofeng; SARASWAT, Neerja; RAMACHANDRAN, Sreekanth; ZHOU, Ding
Patent: WO2011/17125 A1, 2011 ;
反应条件
1: 75 percent / SO2Cl2 / diethyl ether / 0 - 20 °C
2: 26 percent / KOH / H2O / 0.67 h
3: 70 percent / acetic acid / H2O / 0.17 h / 120 °C
View Scheme
参考文献
Chen, Kau-Ming; Semple, J. Edward; Joullie, Madeleine M.
Journal of Organic Chemistry, 1985 , vol. 50, # 21 p. 3997 - 4005
反应条件
1: 77 percent / NaH2PO4; NaClO2 / H2O; dimethylsulfoxide / 20 °C
2: 78 percent / KHCO3 / dimethylformamide / 20 °C
View Scheme
参考文献
Wang, Ping; Zhang, Zhaojun; Yu, Biao
Journal of Organic Chemistry, 2005 , vol. 70, # 22 p. 8884 - 8889
反应条件
1: aqueous HCl; amalgamated zinc
2: aqueous potassium hydrogencarbonate solution
View Scheme
参考文献
Koller; Passler
Monatshefte fuer Chemie, 1930 , vol. 56, p. 212,231
