2,5-二羟基-4-甲基-2,5-二氧代-3-呋喃丙酸合成路线 （共 17 条）
反应条件
hydrogenchloride
12 h; Heating;
参考文献
Deshpande; Natu; Argade
Synthesis, 2001 , # 5 p. 702 - 704
反应条件
1: With potassium hydroxide in ethanol; water
1 h; Reflux;
2: With hydrogenchloride in ethanol; water
pH=2;
参考文献
Takemoto, Hiroyasu; Miyata, Kanjiro; Hattori, Shota; Ishii, Takehiko; Suma, Tomoya; Uchida, Satoshi; Nishiyama, Nobuhiro; Kataoka, Kazunori
Angewandte Chemie - International Edition, 2013 , vol. 52, # 24 p. 6218 - 6221
Angew. Chem., 2013 , vol. 125, # 24 p. 6338 - 6341,4
反应条件
hydrogenchloride in water
pH=2;
参考文献
Wang, Wenjun; Li, Lei; Jin, Chen; Niu, Yujie; Li, Sen; Ma, Ji; Li, Linfeng; Liu, Yu; Cai, Li; Zhao, Wei; Wang, Peng George
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 17 p. 5041 - 5044
反应条件
1: 96 percent / NaH / tetrahydrofuran / 0.5 h
2: 65 percent / 2N aq. KOH / ethanol / 1 h / Heating; extraction at pH 2
View Scheme
参考文献
Naganawa, Atsushi; Ichikawa, Yoshiyasu; Isobe, Minoru
Tetrahedron, 1994 , vol. 50, # 30 p. 8969 - 8982
反应条件
1.1: NaH / benzene / 0.08 h / 20 °C
1.2: 74 percent / benzene / 8 h / 20 °C
2.1: 94 percent / aq. HCl / 12 h / Heating
View Scheme
参考文献
Deshpande; Natu; Argade
Synthesis, 2001 , # 5 p. 702 - 704
反应条件
1.1: sodium hydride / tetrahydrofuran / |Cooling with ice
1.2: 0.5 h / |Cooling with ice
2.1: potassium hydroxide / ethanol; water / 1 h / |Reflux
2.2: pH 2
View Scheme
参考文献
Takemoto, Hiroyasu; Miyata, Kanjiro; Hattori, Shota; Ishii, Takehiko; Suma, Tomoya; Uchida, Satoshi; Nishiyama, Nobuhiro; Kataoka, Kazunori
Angewandte Chemie - International Edition, 2013 , vol. 52, # 24 p. 6218 - 6221
Angew. Chem., 2013 , vol. 125, # 24 p. 6338 - 6341,4
反应条件
1: potassium hydroxide / ethanol / 1 h / Reflux
2: hydrogenchloride / water / pH 2
View Scheme
参考文献
Wang, Wenjun; Li, Lei; Jin, Chen; Niu, Yujie; Li, Sen; Ma, Ji; Li, Linfeng; Liu, Yu; Cai, Li; Zhao, Wei; Wang, Peng George
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 17 p. 5041 - 5044
反应条件
potassium cyanide; hydrogen cyanide
Behandeln des Reaktionsgemisches mit wss. Salzsaeure und Erhitzen des Reaktionsprodukts auf 185grad;
参考文献
Muir; Neuberger
Biochemical Journal, 1949 , vol. 45, p. 163,165
参考文献
Kuester; Weller
Chemische Berichte, 1914 , vol. 47, p. 536
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1917 , vol. 99, p. 247
反应条件
sodium dichromate; acetic acid
参考文献
Kuester
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1898 , vol. 26, p. 323
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1909 , vol. 59, p. 90
