1-(2,4-二羟基苯基)-2-(4-甲氧基苯基)乙酮合成路线 （共 38 条）
反应条件
1: 96 percent / 1,4-diazabicyclo<2.2.2>octane / dimethylformamide / 2 h / Ambient temperature
2: 92 percent / various solvent(s) / 1 h / Heating
3: 73 percent / Raney nickel / ethanol / 1 h / Ambient temperature
4: 82 percent / pyridine, piperidine / 8 h / Heating
View Scheme
参考文献
Levai; Sebok
Synthetic Communications, 1992 , vol. 22, # 12 p. 1735 - 1750
参考文献
Wessely; Lechner
Monatshefte fuer Chemie, 1931 , vol. 57, p. 395,403
反应条件
1: methanol
2: acetic acid anhydride; sodium acetate
View Scheme
参考文献
Wessely; Lechner
Monatshefte fuer Chemie, 1931 , vol. 57, p. 395,403
反应条件
1: 3.3 g / K2CO3, KI / acetone / 4 h / Heating
2: 1.) NaH / 1.) THF, 40-50 deg C, 2.) 35-40 deg C, 3 h
3: 87.3 percent / conc. HCl, gl. acetic acid / 1 h / Heating
View Scheme
参考文献
Jain, A. C.; Paliwal, Poonam
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1988 , vol. 27, # 1-12 p. 985 - 988
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran
T=20°C; Mitsunobu reaction; 0.0833333 h;
参考文献
Kim, Young-Woo; Hackett, John C.; Brueggemeier, Robert W.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 16 p. 4032 - 4040
反应条件
potassium carbonate in acetone
Heating;
参考文献
Kumar, Vijayendra; Kumar, Rajesh; Raunak; Poonam; Sharma, Sunil K; Prasad, Ashok K; Cholli, Ashok L; Olsen, Carl E; Parmar, Virinder S
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2007 , vol. 46, # 9 p. 1501 - 1510
参考文献
Bradbury; White
Journal of the Chemical Society, 1951 , p. 3447
反应条件
potassium carbonate; acetone
参考文献
Badcock et al.
Journal of the Chemical Society, 1950 , p. 2961,2963
