1-(2,4-二羟基苯基)-2-(4-甲氧基苯基)乙酮合成路线 （共 38 条）
反应条件
AlCl3, aluminium chloride
T=100 - 150°C; 3.5 h;
参考文献
HANBUL COSMETIC CO., LTD.
Patent: WO2005/54169 A1, 2005 ;
Location in patent: Page/Page column 8; 9 ;
反应条件
hydrogen fluoride
T=20°C; Friedel-Crafts acylation; 12 h; autoclave; Product distribution / selectivity;
参考文献
Pazenok, Sergii; Lui, Norbert
Patent: US2010/121082 A1, 2010 ;
Location in patent: Page/Page column 2 ;
反应条件
boron trifluoride diethyl etherate
T=85°C; Acylation; Friedel Crafts; 1.5 h;
参考文献
Balasubramanian, Sreenivasan; Nair, Muraleedharan G.
Synthetic Communications, 2000 , vol. 30, # 3 p. 469 - 484
反应条件
hydrogenchloride; diethyl ether
Erhitzen des Reaktionsprodukts mit Wasser;
参考文献
Walz
Justus Liebigs Annalen der Chemie, 1931 , vol. 489, p. 118,127, 140
参考文献
Virtanen; Hietala
Acta Chemica Scandinavica (1947-1973), 1958 , vol. 12, p. 579
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Bradbury; White
Journal of the Chemical Society, 1951 , p. 3447
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Bose; Siddiqui
Journal of Scientific and Industrial Research, 1951 , vol. 10 B, p. 291,292
参考文献
Whalley
Journal of the Chemical Society, 1957 , p. 1833,1834
反应条件
1: AlCl3; nitrobenzene / Erwaermen des Reaktionsprodukts mit wss. KOH
2: copper; quinoline
View Scheme
参考文献
Whalley
Journal of the Chemical Society, 1957 , p. 1833,1834
反应条件
1: acetic acid anhydride / 100 °C
2: diethyl ether; hydrogen chloride; zinc chloride / 0 °C / und Erhitzen des Reaktionsprodukts mit Wasser
View Scheme
参考文献
Baker; Eastwood
Journal of the Chemical Society, 1929 , p. 2907
反应条件
1: AlCl3; nitrobenzene / Erwaermen des Reaktionsprodukts mit wss. KOH
2: copper; quinoline
View Scheme
参考文献
Whalley
Journal of the Chemical Society, 1957 , p. 1833,1834
反应条件
1: potassium carbonate / N,N-dimethyl-formamide
2: sodium hydride / toluene / Reflux
3: anhydrous iron chloride; silica gel / 1,2-dichloro-ethane
4: AlCl3, aluminium chloride / dichloromethane
View Scheme
参考文献
Tang, Lina; Pang, Yongle; Yan, Qiao; Shi, Liuqing; Huang, Jianhui; Du, Yunfei; Zhao, Kang
Journal of Organic Chemistry, 2011 , vol. 76, # 8 p. 2744 - 2752
