1,2-苯并异唑-3-乙酸合成路线 （共 23 条）
反应条件
1: With hydroxylamine in water T=20 - 95°C; pH=4.5 - > 8.0; 12 - 24 h; 2: With hydrogenchloride; water T=0 - 10°C; pH=1 - 1.5; 1 h; Product distribution / selectivity;
参考文献
BATTULA, Srinivasa, Reddy
Patent: WO2008/26217 A1, 2008 ;
Location in patent: Page/Page column 4; 5-6 ;
反应条件
hydroxylamine hydrochloride; sodium methylate in methanol; anhydrous sodium hydrogen carbonate
参考文献
American Cyanamid Company
Patent: US5484763 A1, 1996 ;
反应条件
methanol; hydroxylamine hydrochloride; sodium methylate 5 - 10 h; Heating / reflux;
参考文献
WOCKHARDT LIMITED
Patent: WO2005/44808 A1, 2005 ;
Location in patent: Page/Page column 9 ;
反应条件
1: With sodium hydroxide; hydroxylammonium sulfate in water; 1,2-dichloro-ethane T=84 - 86°C; 4 h; 2: With sulfuric acid in water pH=1 - 2; Product distribution / selectivity;
参考文献
Ueno, Yoshikazu; Ishikura, Tsutomu
Patent: US2005/215796 A1, 2005 ;
Location in patent: Page/Page column 3 ;
反应条件
1: (i) KOEt, EtOH, Et2O, (ii) /BRN= 114579/ 2: KOEt / ethanol / 18 h / Heating 3: aq. Na2CO3, H2O2 View Scheme
参考文献
Casini,G. et al.
Journal of Heterocyclic Chemistry, 1965 , vol. 2, p. 385 - 386
反应条件
1: KOEt / ethanol / 18 h / Heating 2: aq. Na2CO3, H2O2 View Scheme
参考文献
Casini,G. et al.
Journal of Heterocyclic Chemistry, 1965 , vol. 2, p. 385 - 386
反应条件
dihydrogen peroxide; sodium carbonate
参考文献
Casini,G. et al.
Journal of Heterocyclic Chemistry, 1965 , vol. 2, p. 385 - 386
反应条件
hydrogenchloride in methanol
参考文献
Ricci, Ada; Amorosi, Sonia; Maggiali, Cesare A.; Ronchini, Ferdinando; Bassi, Maria; Branca, Camillo
Phytochemistry (Elsevier), 1995 , vol. 38, # 4 p. 817 - 820
反应条件
in methanol; diethyl ether T=0 - 20°C;
参考文献
Fallan, Charlene; Lam, Hon Wai
Chemistry - A European Journal, 2012 , vol. 18, # 36 p. 11214 - 11218
反应条件
sulfuric acid 1.5 h; Heating;
参考文献
Jain, Monish; Kwon, Chul-Hoon
Journal of Medicinal Chemistry, 2003 , vol. 46, # 25 p. 5428 - 5436
