1: With ammonium chloride; [RhCl(η2:η2-cycloocta-1,5-diene)]2; (R)-(S)-PPF-PtBu2 in methanol
T=20°C; 1 h;
2: With hydrogen in methanol
T=50°C; P=5171.62 Torr; 18 h; Product distribution / selectivity;
参考文献
MERCK and CO., INC.
Patent: WO2006/81151 A1, 2006 ;
Location in patent: Page/Page column 14; 15-16 ;
1: With ammonium formate; [RhCl(η2:η2-cycloocta-1,5-diene)]2; (R)-(S)-PPF-PtBu2 in methanol
T=55°C; 5 h;
2: With hydrogen in methanol
T=55°C; P=12929 Torr; 20 h; Product distribution / selectivity;
参考文献
MERCK and CO., INC.
Patent: WO2006/81151 A1, 2006 ;
Location in patent: Page/Page column 16 ;
1: With sodium tetrahydroborate; boron trifluoride diethyl etherate in tetrahydrofuran
T=-10 - 20°C; 2 h;
2: With hydrogenchloride in tetrahydrofuran; methanol; water
T=0 - 40°C; 1 h;
3: With hydrogen; palladium-on-charcoal in methanol
12 h;
参考文献
DAEWOONG PHARMACEUTICAL CO., LTD.; CHOI, Soo Jin; LEE, Byung Goo; OH, Seong Soo; KIM, Yong Tae; EO, Jin Yong; KIM, Hung Sop
Patent: WO2012/148246 A2, 2012 ;
Location in patent: Page/Page column 15; 16 ;
