2-甲氧基-5-三氟甲基苯甲酸合成路线 （共 6 条）
反应条件
1: methyl 4-(trifluoromethyl)phenyl ether With n-butyllithium; potassium tert-butylate in tetrahydrofuran T=-78°C; 4 h; 2: carbon dioxide in tetrahydrofuran T=-78 - 25°C; 1.5 h;
参考文献
WO2011/25982 A2, ;
Page/Page column 145 ;
反应条件
1: 2-bromo-1-methoxy-4-(trifluoromethyl)benzene; isopropylmagnesium chloride With lithium chloride in tetrahydrofuran; diethyl ether T=20°C; 15 h; 2: carbon dioxide in tetrahydrofuran; diethyl ether T=-78 - 20°C; 3: With hydrogenchloride; potassium carbonate more than 3 stages;
参考文献
US2007/88070 A1, ;
Page/Page column 17 ;
US 20070088070 A1
反应条件
1.1: potassium carbonate / acetone / 25 °C 2.1: potassium tert-butylate; n-butyllithium / tetrahydrofuran / 4 h / -78 °C 2.2: 1.5 h / -78 - 25 °C View Scheme
反应条件
1-trans-IODO-4-CYCLOHEXYL in N,N-dimethyl-formamide 4 h; Reflux;
参考文献
GLAXO GROUP LIMITED; GLAXOSMITHKLINE (CHINA) RandD COMPANY LIMITED; NICHOLS, Paula Louise; EATHERTON, Andrew John; BAMBOROUGH, Paul; JANDU, Karamjit Singh; PHILPS, Oliver James; ANDREOTTI, Daniele
Patent: WO2011/38572 A1, 2011 ;
Location in patent: Page/Page column 82 ;
WO 2011/038572 A1
反应条件
oxalyl dichloride; N,N-dimethyl-formamide in tetrahydrofuran
1 h; Ambient temperature;
参考文献
Abbott Laboratories
Patent: US2009/247500 A1, 2009 ;
Location in patent: Page/Page column 21 ;
US 20090247500 A1
