3-甲基异恶唑-5-甲酸合成路线 （共 25 条）
反应条件
1: With sodium hydroxide; water in tetrahydrofuran; methanol T=20°C; 18 - 20 h; 2: With hydrogenchloride in tetrahydrofuran; methanol; water pH=2;
参考文献
MILLENNIUM PHARMACEUTICALS, INC.
Patent: WO2006/91674 A1, 2006 ;
Location in patent: Page/Page column 79 ;
WO 2006/091674 A1
反应条件
Jone's reagent in acetone T=0°C; 3 h;
参考文献
Choi, Min Jeong; No, Eun Sun; Thorat, Dhanaji Achyutrao; Jang, Jae Wan; Yang, Hakkyun; Lee, Jaeick; Choo, Hyunah; Kim, Soo Jin; Lee, Chang Sik; Ko, Soo Young; Lee, Jiyoun; Nam, Ghilsoo; Pae, Ae Nim
Journal of Medicinal Chemistry, 2013 , vol. 56, # 22 p. 9008 - 9018
反应条件
sulfuric acid; hydroxylamine hydrochloride T=100°C; Cyclization; hydrolysis; 12 h;
参考文献
Martins, Marcos A. P.; Flores, Alex F. C.; Bastos, Giovani P.; Sinhorin, Adilson; Bonacorso, Helio G.; Zanatta, Nilo
Tetrahedron Letters, 2000 , vol. 41, # 3 p. 293 - 297
反应条件
sulfuric acid in water T=75 - 100°C;
参考文献
Martins, Marcos A.P.; Brondani, Sergio; Leidens, Victor L.; Flores, Darlene C.; Moura, Sidnei; Zanatta, Nilo; Hoerner, Manfredo; Flores, Alex F.C.
Canadian Journal of Chemistry, 2005 , vol. 83, # 8 p. 1171 - 1177
反应条件
1: 72 percent / H2NOH*HCl, 20percent aq. NaOH / 2 h / Ambient temperature 2: 75 percent / conc. H2SO4 / ethanol / 5 h / Heating 3: 61.2 percent / 10percent aq. NaOH / ethanol / Ambient temperature View Scheme
参考文献
Lepage; Tombret; Cuvier; Marivain; Gillardin
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 6 p. 581 - 593
反应条件
1: 75 percent / conc. H2SO4 / ethanol / 5 h / Heating 2: 61.2 percent / 10percent aq. NaOH / ethanol / Ambient temperature View Scheme
参考文献
Lepage; Tombret; Cuvier; Marivain; Gillardin
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 6 p. 581 - 593
反应条件
1: NH2OH*HCl, NaOAc / ethanol 2: aq. H2O2, KOH View Scheme
参考文献
Takahashi,K. et al.
Chemical and Pharmaceutical Bulletin, 1962 , vol. 10, p. 607 - 611
反应条件
potassium permanganate in acetone Ambient temperature;
参考文献
Vagina,L.K. et al.
Zhurnal Organicheskoi Khimii, 1966 , vol. 2, p. 417 - 423,414 - 420
反应条件
chloranil in xylene 21 h; Heating;
参考文献
Vagina,L.K.; Chistokletov,V.N.
Journal of Organic Chemistry USSR (English Translation), 1966 , vol. 2, p. 1736 - 1739
Zhurnal Organicheskoi Khimii, 1966 , vol. 2, p. 1766 - 1769
反应条件
sulfuric acid Hydrolysis; Heating;
参考文献
Martins, Marcos A. P.; Flores, Alex F. C.; Bastos, Giovani P.; Sinhorin, Adilson; Bonacorso, Helio G.; Zanatta, Nilo
Tetrahedron Letters, 2000 , vol. 41, # 3 p. 293 - 297
