1-苯基-1,3-丙二醇合成路线 （共 84 条）
反应条件
1: With trimethylsilyl trifluoromethanesulfonate; 1,1,1,3,3,3-hexamethyl-disilazane 2: With trimethylsilyl trifluoromethanesulfonate; (-)-menthone 3: With hydrogenchloride in methanol
参考文献
Liang, Yuzeng; Narayanasamy, Janarthanan; Schinazi, Raymond F.; Chu, Chung K.
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 7 p. 2178 - 2189
反应条件
1,3-dibromo-5,5-dimethyl-hydantoin; 2,6-di-tert-butyl-4-methyl-phenol in acetonitrile T=20°C; 1 h; Inert atmosphere;
参考文献
Maegawa, Tomohiro; Koutani, Yasuyuki; Otake, Kazuki; Fujioka, Hiromichi
Journal of Organic Chemistry, 2013 , vol. 78, # 7 p. 3384 - 3390
反应条件
tributylphosphine in tetrahydrofuran 1 h; Ambient temperature;
参考文献
Synlett, , vol. 1997, # 11 p. 1247 - 1248
反应条件
1.1: 95 percent / Et3N / CH2Cl2 / 0 h / -10 °C 2.1: O2; (-)-sparteine; 3 Angstroem sieves / Pd(OAc)2 / toluene / 36 h / 80 °C / 760 Torr 2.2: H2O / tetrahydrofuran / 65 °C View Scheme
参考文献
Ali, Iliyas Sayyed; Sudalai, Arumugam
Tetrahedron Letters, 2002 , vol. 43, # 31 p. 5435 - 5436
反应条件
1.1: triethylamine 2.1: 3 h / Reflux 3.1: potassium hydroxide / 1.5 h / 100 - 105 °C 3.2: 4 h / 140 - 145 °C 4.1: AlCl3, aluminium chloride / dichloromethane / 10 - 25 °C View Scheme
参考文献
Synthetic Communications, , vol. 41, # 11 p. 1565 - 1571
反应条件
1: 95 percent / p-toluenesulfonic acid monohydrate / benzene / Heating 2: (4S)-4-benzyl-3-mesyl-2-phenyl-1,3,2-oxazaborolidin-5-one; dimethyl-(2-methyl-2-propenyl)phenylsilane / CH2Cl2 / 24 h / -50 °C 3: 1N HCl / ethanol / Heating View Scheme
参考文献
Harada, Toshiro; Egusa, Takayuki; Igarashi, Yasuto; Kinugasa, Motoharu; Oku, Akira
Journal of Organic Chemistry, 2002 , vol. 67, # 20 p. 7080 - 7090
反应条件
1: With trimethylsilyl trifluoromethanesulfonate; 1,1,1,3,3,3-hexamethyl-disilazane 2: With trimethylsilyl trifluoromethanesulfonate; (-)-menthone 3: With hydrogenchloride in methanol
参考文献
Liang, Yuzeng; Narayanasamy, Janarthanan; Schinazi, Raymond F.; Chu, Chung K.
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 7 p. 2178 - 2189
反应条件
hydrogen; Pd catalyst in butan-1-ol T=100°C; other catalysts; Kinetics;
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 52, # 8 p. 2019 - 2027
反应条件
1.1: FeCl3·6H2O / dichloromethane / 24 h / |Reflux 2.1: sodium hydroxide / dichloromethane; water / 1 h / 40 °C 3.1: triethylamine / water / 2 h / 0 °C 4.1: acetonitrile / 12 h / |Reflux 5.1: sodium hydroxide / methanol; water / 4 h / |Reflux 5.2: 1 h / 20 °C 6.1: sodium hydroxide; sodium carbonate / dichloromethane; water / 1 h / 20 °C 6.2: 1 h / |Reflux View Scheme
参考文献
De Castro, Kathlia A.; Jungnam, Ko; Daejong, Park; Sungdae, Park; Hakjune, Rhee
Organic Process Research and Development, 2007 , vol. 11, # 5 p. 918 - 921
反应条件
hydrogen; Pd catalyst in butan-1-ol T=100°C; other catalysts; Kinetics;
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 52, # 8 p. 2019 - 2027
