羟辛可芬合成路线

参考文献

SmithKline Beecham S.p.A.
Patent: US6355654 B1, 2002 ;
Location in patent: Page column 16 ;

485-89-2羟辛可芬+

3789-59-1(S)-(-)-1-苯丙胺

174636-32-9(-)-(S)-N-(alpha-乙基苄基)-3-羟基-2-苯基喹啉-4-羧酰胺

参考文献

Rohbogner, Christoph J.; Wirth, Stefan; Knochel, Paul
Organic Letters, 2010 , vol. 12, # 9 p. 1984 - 1987

485-89-2羟辛可芬

174636-32-9(-)-(S)-N-(alpha-乙基苄基)-3-羟基-2-苯基喹啉-4-羧酰胺

参考文献

Giardina, Giuseppe A. M.; Raveglia, Luca F.; Grugni, Mario; Sarau, Henry M.; Farina, Carlo; Medhurst, Andrew D.; Graziani, Davide; Schmidt, Dulcie B.; Rigolio, Roberto; Luttmann, Mark; Cavagnera, Stefano; Foley, James J.; Vecchietti, Vittorio; Hay, Douglas W. P.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 6 p. 1053 - 1065

1000007-26-0

485-89-2羟辛可芬

参考文献

Boudet, Nadege; Lachs, Jennifer R.; Knochel, Paul
Organic Letters, 2007 , vol. 9, # 26 p. 5525 - 5528

1224598-16-6

485-89-2羟辛可芬

参考文献

Rohbogner, Christoph J.; Wirth, Stefan; Knochel, Paul
Organic Letters, 2010 , vol. 12, # 9 p. 1984 - 1987

2243-35-82-乙酰氧基苯乙酮+

91-56-5吲哚-2,3-二酮

485-89-2羟辛可芬

参考文献

Janz, Kristin; Kaila, Neelu
Journal of Organic Chemistry, 2009 , vol. 74, # 22 p. 8874 - 8877

41957-64-63-甲氧基-2-苯基喹啉-4-羧酸

485-89-2羟辛可芬

参考文献

Giardina, Giuseppe A. M.; Raveglia, Luca F.; Grugni, Mario; Sarau, Henry M.; Farina, Carlo; Medhurst, Andrew D.; Graziani, Davide; Schmidt, Dulcie B.; Rigolio, Roberto; Luttmann, Mark; Cavagnera, Stefano; Foley, James J.; Vecchietti, Vittorio; Hay, Douglas W. P.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 6 p. 1053 - 1065

2243-35-82-乙酰氧基苯乙酮+

7631-34-7

485-89-2羟辛可芬

参考文献

SmithKline Beecham Corporation
Patent: US6335448 B1, 2002 ;
Location in patent: Example 1 ;

4079-52-12-甲氧基苯乙酮

485-89-2羟辛可芬

参考文献

Giardina, Giuseppe A. M.; Raveglia, Luca F.; Grugni, Mario; Sarau, Henry M.; Farina, Carlo; Medhurst, Andrew D.; Graziani, Davide; Schmidt, Dulcie B.; Rigolio, Roberto; Luttmann, Mark; Cavagnera, Stefano; Foley, James J.; Vecchietti, Vittorio; Hay, Douglas W. P.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 6 p. 1053 - 1065

91-56-5吲哚-2,3-二酮

485-89-2羟辛可芬

参考文献

Giardina, Giuseppe A. M.; Raveglia, Luca F.; Grugni, Mario; Sarau, Henry M.; Farina, Carlo; Medhurst, Andrew D.; Graziani, Davide; Schmidt, Dulcie B.; Rigolio, Roberto; Luttmann, Mark; Cavagnera, Stefano; Foley, James J.; Vecchietti, Vittorio; Hay, Douglas W. P.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 6 p. 1053 - 1065