反应条件
1.1: H2 / Pd/C / methanol / 27 h / 20 °C 2.1: aq. HBr; NaNO2 / 0 - 5 °C 2.2: CuBr; aq. HBr / 60 °C 3.1: LDA / tetrahydrofuran; hexane / 1.5 h / -78 °C 3.2: tetrahydrofuran; hexane / -78 - 20 °C 4.1: oxalyl chloride; DMF / CH2Cl2 / 20 °C 5.1: n-BuLi / hexane; tetrahydrofuran / -78 °C 5.2: 4.70 g / hexane; tetrahydrofuran; CH2Cl2 / -78 - 10 °C View Scheme
参考文献
Wang, Qiuping; Lucien, Edlaine; Hashimoto, Akihiro; Pais, Godwin C. G.; Nelson, David M.; Song, Yongsheng; Thanassi, Jane A.; Marlor, Christopher W.; Thoma, Christy L.; Cheng, Jijun; Podos, Steven D.; Ou, Yangsi; Deshpande, Milind; Pucci, Michael J.; Buechter, Douglas D.; Bradbury, Barton J.; Wiles, Jason A.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 2 p. 199 - 210