2-甲基-3-硝基苯甲醚合成路线 （共 34 条）
反应条件
1: N,N-dimethyl-formamide / 3 h / |Reflux
2: zinc; acetic acid; hydrogenchloride / water / 0.5 h / 20 °C
3: 4-(N,N-dimethlyamino)pyridine / acetonitrile / 20 °C
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参考文献
SANOFI; ARNAUD, Joëlle; ARTIAGA, Martine; BARTH, Francis; HORTALA, Laurent; MARTINEZ, Serge; ROUX, Pascale
Patent: WO2013/87643 A1, 2013 ;
反应条件
1: potassium ethylate; diethyl ether
2: hydrogen peroxide; NaOH-solution
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参考文献
Blaikie; Perkin
Journal of the Chemical Society, 1924 , vol. 125, p. 313
反应条件
(i) KOEt, Et2O, (ii) H2O2; Multistep reaction;
参考文献
Beckett,A.H. et al.
Tetrahedron, 1968 , vol. 24, p. 6093 - 6109
反应条件
1: tin; aqueous hydrochloric acid
2: aqueous H2SO4 / Diazotization
View Scheme
参考文献
GLAXO GROUP LIMITED; ALVARO, Giuseppe; DECOR, Anne; FONTANA, Stefano; HAMPRECHT, Dieter; LARGE, Charles; MARASCO, Agostino
Patent: WO2011/69951 A1, 2011 ;
WO 2011/069951 A1
