N-苯甲酰-2'-脱氧胞苷合成路线 （共 36 条）
反应条件
1: pyridine / 0.5 h / 20 °C 2: pyridine / 4 h / 20 °C 3: aq. NH4OH / 0.25 h / 20 °C View Scheme
参考文献
Charubala, R.; Uhlmann, E.; Beiter, A. H.; Pfleiderer, W.
Synthesis, 1984 , # 11 p. 965 - 968
反应条件
in water; acetonitrile Hydrolysis; Irradiation;
参考文献
Coleman, Michael P.; Boyd, Mary K.
Tetrahedron Letters, 1999 , vol. 40, # 45 p. 7911 - 7915
反应条件
ammonium hydroxide in water T=0°C; Hydrolysis; 0.333333 h;
参考文献
Busson; Kerremans; Van Aerschot; Peeters; Blaton; Herdewijn
Nucleosides and Nucleotides, 1999 , vol. 18, # 4-5 p. 1079 - 1082
反应条件
Candida antarctica lipase B; phosphate buffer in 1,4-dioxane pH=7;
参考文献
Garcia, Javier; Fernandez, Susana; Ferrero, Miguel; Sanghvi, Yogesh S.; Gotor, Vicente
Journal of Organic Chemistry, 2002 , vol. 67, # 13 p. 4513 - 4519
反应条件
1: 90 percent / dicyclohexylcarbodiimide / dimethylformamide / 1 h / 0 °C 2: 90 percent / pyridine / 5 h / 80 °C View Scheme
参考文献
Igolen, Jean; Morin, Christophe
Journal of Organic Chemistry, 1980 , vol. 45, # 23 p. 4802 - 4804
参考文献
Gilead Sciences, Inc.
Patent: US5672697 A1, 1997 ;
反应条件
in pyridine T=80°C; 15 h;
参考文献
Igolen, Jean; Morin, Christophe
Journal of Organic Chemistry, 1980 , vol. 45, # 23 p. 4802 - 4804
反应条件
in pyridine T=85°C; 7.5 h;
参考文献
Finlay, M.; Debiard, J. P.; Guy, A.; Molko, D.; Teoule, R.
Synthesis, 1983 , # 4 p. 303 - 304
反应条件
1: 98 percent / iPr2NEt; DMAP / dimethylformamide / 0.02 h / microwave irradiation 2: 98 percent / 0.2 N NaOH / pyridine; methanol / 0 h / microwave irradiation View Scheme
参考文献
Rao; Kumar; Chauhan; Garg; Gupta
Nucleosides, Nucleotides and Nucleic Acids, 2002 , vol. 21, # 4-5 p. 393 - 400
反应条件
1: 2 h / 20 °C 2: NH4OH / H2O / 0.33 h / 0 °C View Scheme
参考文献
Busson; Kerremans; Van Aerschot; Peeters; Blaton; Herdewijn
Nucleosides and Nucleotides, 1999 , vol. 18, # 4-5 p. 1079 - 1082
