2,2-二甲基-3-羟基丙酸合成路线 （共 51 条）
反应条件
water; lithium hydroxide hydrate in tetrahydrofuran; methanol T=0 - 20°C; 1.5 h;
参考文献
Finch, Orla C.; Furkert, Daniel P.; Brimble, Margaret A.
Tetrahedron, 2014 , vol. 70, # 3 p. 590 - 596
反应条件
sodium hydroxide in water
参考文献
FMC Corporation
Patent: US4405357 A1, 1983 ;
反应条件
hydrogenchloride; water T=50°C; 3 h;
参考文献
Rit, Raja K.; Yadav, M. Ramu; Sahoo, Akhila K.
Organic Letters, 2012 , vol. 14, # 14 p. 3724 - 3727
反应条件
1: With [Rh(acac)2(CO)2]; 2-isopropoxy-1-methyl-3-phenyl-2,3-dihydro-1H-benzo[d][1,3]azaphosphole; hydrogen; toluene-4-sulfonic acid in benzene T=45°C; P=20686.5 Torr; 12 h; 2: With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene in water; tert-butyl alcohol T=20°C; regioselective reaction;
参考文献
Sun; Frimpong; Tan
Journal of the American Chemical Society, 2010 , vol. 132, # 34 p. 11841 - 11843
反应条件
1: bromine / 150 °C 2: Hydrolysis View Scheme
参考文献
Kharasch; Fineman
Journal of the American Chemical Society, 1941 , vol. 63, p. 2778
反应条件
1 Pd/TiO2; oxygen; sodium hydroxide T=80°C; P=2250.23 Torr; 24 h;
参考文献
D'Agostino, Carmine; Kotionova, Tatyana; Mitchell, Jonathan; Miedziak, Peter J.; Knight, David W.; Taylor, Stuart H.; Hutchings, Graham J.; Gladden, Lynn F.; Mantle, Mick D.
Chemistry - A European Journal, 2013 , vol. 19, # 35 p. 11725 - 11732
反应条件
potassium permanganate
参考文献
Tanner,D.D. et al.
Canadian Journal of Chemistry, 1977 , vol. 55, p. 612 - 618
反应条件
sodium hydroxide; oxygen; palladium/alumina T=39.85°C; P=760 Torr; Kinetics; Further Variations:Temperatures;
参考文献
Wessely
Monatshefte fuer Chemie, 1900 , vol. 21, p. 220
反应条件
1 Au-Pd/TiO2; oxygen; sodium hydroxide T=80°C; P=2250.23 Torr; 4 h;
参考文献
Kotionova, Tatyana; Lee, Christopher; Miedziak, Peter J.; Dummer, Nicholas F.; Willock, David J.; Carley, Albert F.; Morgan, David J.; Knight, David W.; Taylor, Stuart H.; Hutchings, Graham J.
Catalysis Letters, 2012 , vol. 142, # 9 p. 1114 - 1120
参考文献
Kharasch; Fineman
Journal of the American Chemical Society, 1941 , vol. 63, p. 2778
