3,3-二甲基-2-氧代吡咯烷合成路线 （共 8 条）
反应条件
Lawesson's reagent in toluene 0.5 h; Heating;
参考文献
Padwa, Albert; Coats, Steven J.; Hadjiarapoglou, Lazaros
Heterocycles, 1994 , vol. 39, # 1 p. 219 - 242
Title/Abstract Full Text View citing articles Show Details
Padwa, Albert; Coats, Steven J.; Hadjiarapoglou, Lazaros
Heterocycles, 1995 , vol. 41, # 8 p. 1631 - 1652
反应条件
hydrogenchloride in diethyl ether
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: EP996618 B1, 2003 ;
Location in patent: Page/Page column 8 ;
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran
T=5 - 20°C; 2.5 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2007/16364 A2, 2007 ;
Location in patent: Page/Page column 26; 28-29 ;
反应条件
1: 1-(Trimethylsilyl)-2-pyrrolidinone; methyl iodide With lithium diisopropyl amide in tetrahydrofuran; hexane
T=-78 - -20°C; 0.25 h;
2: methyl iodide With lithium diisopropyl amide in tetrahydrofuran; hexane
T=25°C; Further stages.;
参考文献
Ahn; Cardenas; Yang; Romo
Organic letters, 2001 , vol. 3, # 5 p. 751 - 754
反应条件
1: 1-(Trimethylsilyl)-2-pyrrolidinone With lithium diisopropyl amide in tetrahydrofuran; hexane
T=-78°C; 1 h;
2: methyl iodide in tetrahydrofuran; hexane
T=-78 - 0°C; 12 h;
参考文献
SUNOVION PHARMACEUTICALS INC.; HARDY, Larry, Wendell; HEFFERNAN, Michele, L., R.; WU, Frank, Xinhe; SPEAR, Kerry, L.; SARASWAT, Lakshmi, D.
Patent: WO2011/75699 A2, 2011 ;
Location in patent: Page/Page column 140-141 ;
WO 2011/075699 A1
反应条件
nickel in ethanol
T=60°C; 1 h;
参考文献
Milewska, Maria J.; Bytner, Tomasz; Polonski, Tadeusz
Synthesis, 1996 , # 12 p. 1485 - 1488
反应条件
triphenylmethyl-sodium in tetrahydrofuran
48 h;
参考文献
Stamm, Helmut; Woderer, Anton; Wiesert, Wolfgang
Chemische Berichte, 1981 , vol. 114, # 1 p. 32 - 48
反应条件
1: 51 percent / Lawesson's reagent / toluene / 0.5 h / Heating
2: 75 percent / Raney-Ni / ethanol / 1 h / 60 °C
View Scheme
参考文献
Milewska, Maria J.; Bytner, Tomasz; Polonski, Tadeusz
Synthesis, 1996 , # 12 p. 1485 - 1488
