3-甲基-1,2-苯并异恶唑合成路线 （共 20 条）
反应条件
trifluoromethylsulfonic anhydride in dichloromethane T=20°C; 5 h; Inert atmosphere;
参考文献
Kalkhambkar, Rajesh G.; Yuvaraj
Synthetic Communications, 2014 , vol. 44, # 4 p. 547 - 555
反应条件
N-chloro-succinimide; potassium carbonate in tetrahydrofuran T=20°C; 12 h; Inert atmosphere;
参考文献
Chen, Cheng-Yi; Andreani, Teresa; Li, Hongmei
Organic Letters, 2011 , vol. 13, # 23 p. 6300 - 6303
反应条件
acetic anhydride; potassium carbonate in water; ethyl acetate; N,N-dimethyl-formamide
参考文献
Andersson, Carl-Magnus A.; Fribert, Bo Lennart M.; Skjaerbaek, Niels; Spalding, Tracy A.; Uldam, Allan K.
Patent: US2002/37886 A1, 2002 ;
US 20020037886 A1
反应条件
triethyl phosphite in toluene 45 h; Heating;
参考文献
Boulton, A. J.; Tsoungas, Petros G.; Tsiamis, Chris
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 695 - 698
反应条件
1: With sodium t-butanolate in tetrahydrofuran T=23°C; 0.5 h; Inert atmosphere; 2: With copper(l) iodide; N-methyl-2-(methylamino)ethylamine in tetrahydrofuran T=23°C; 0.166667 h; Inert atmosphere;
参考文献
Udd, Sandra; Jokela, Reija; Franzen, Robert; Tois, Jan
Tetrahedron Letters, 2010 , vol. 51, # 7 p. 1030 - 1033
反应条件
1: 85 percent / sodium acetate hydroxylamine hydrochloride / H2O; ethanol / 1.) reflux, 0.5h 2: 75 percent / 1 h / Ambient temperature 3: 87 percent / 1.) 170-180 deg C, 1h, 2.) 100 deg C, 1h View Scheme
参考文献
BIOENERGENIX; MCCALL, John; KELLY, Robert, C.; ROMERO, Donna, L.
Patent: WO2014/66795 A1, 2014 ;
反应条件
N-chloro-succinimide; potassium carbonate in tetrahydrofuran; water T=20°C; 12 h; Inert atmosphere;
参考文献
Chen, Cheng-Yi; Andreani, Teresa; Li, Hongmei
Organic Letters, 2011 , vol. 13, # 23 p. 6300 - 6303
反应条件
trichloromethylcarbonyl isocyanate in tetrahydrofuran 0.166667 h; Ambient temperature;
参考文献
Stokker, Gerald
Journal of Organic Chemistry, 1983 , vol. 48, # 15 p. 2613 - 2615
反应条件
1: ammonia / methanol / 2 h / 20 °C / Inert atmosphere 2: N-chloro-succinimide; diisopropylamine / acetonitrile / 12 h / 20 °C / Inert atmosphere View Scheme
参考文献
Chen, Cheng-Yi; Andreani, Teresa; Li, Hongmei
Organic Letters, 2011 , vol. 13, # 23 p. 6300 - 6303
反应条件
1.) 170-180 deg C, 1h, 2.) 100 deg C, 1h;
参考文献
Ranganathan, S.; Ranganathan, D.; Ramachandran, P. V.; Mahanty, M. K.; Bamezai, S.
Tetrahedron, 1981 , vol. 37, # 24 p. 4171 - 4184
