N-对甲苯磺酰-L-谷氨酸合成路线 （共 12 条）
反应条件
1: With sodium hydroxide T=70°C; 2: With hydrogenchloride T=0°C; pH=~ 3;
参考文献
INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A.CHINA
Patent: US2011/306633 A1, 2011 ;
Location in patent: Page/Page column 4 ;
反应条件
trifluoroacetic acid in dichloromethane T=20°C;
参考文献
Blank, Brian R.; Alayoglu, Pinar; Engen, William; Choi, Joseph K.; Berkman, Clifford E.; Anderson, Marc O.
Chemical Biology and Drug Design, 2011 , vol. 77, # 4 p. 241 - 247
反应条件
1: triethylamine / dichloromethane / 1 h 2: trifluoroacetic acid / dichloromethane / 20 °C View Scheme
参考文献
Blank, Brian R.; Alayoglu, Pinar; Engen, William; Choi, Joseph K.; Berkman, Clifford E.; Anderson, Marc O.
Chemical Biology and Drug Design, 2011 , vol. 77, # 4 p. 241 - 247
反应条件
acetyl chloride 2 h; Heating;
参考文献
Srikanth; Kumar; Ghosh, Balaram; Jha, Tarun
Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 7 p. 2119 - 2131
反应条件
1: CHCl3; PCl3 2: water; NH3 3: aqueous HBr; acetic acid; phenol View Scheme
参考文献
Rudinger et al.
Collection of Czechoslovak Chemical Communications, 1959 , vol. 24, p. 2013,2014,2016
反应条件
1: PPA / 2 h / Heating 2: 78 percent / NH3 3: PPA / 2 h / Heating View Scheme
参考文献
De, A. U.; Pandey, Jiten; Majumdar, Anjali
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 5 p. 481 - 483
反应条件
1: SOCl2
2: CHCl3; NaHCO3; H2O
3: palladium/charcoal; acetic acid; aqueous ethanol / Hydrogenation
4: water; NH3
5: sodium; liquid NH3
View Scheme
参考文献
Rudinger
Collection of Czechoslovak Chemical Communications, 1954 , vol. 19, p. 365,373
反应条件
1: SOCl2
2: CHCl3; NaHCO3; H2O
3: palladium/charcoal; acetic acid; aqueous ethanol / Hydrogenation
4: aq. NaOH solution
5: sodium; NH3
View Scheme
参考文献
Rudinger
Collection of Czechoslovak Chemical Communications, 1954 , vol. 19, p. 365,373
反应条件
1: PPA / 2 h / Heating
2: 76 percent
View Scheme
参考文献
De, A. U.; Pandey, Jiten; Majumdar, Anjali
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 5 p. 481 - 483
反应条件
1: PPA / 2 h / Heating
2: 67 percent
View Scheme
参考文献
De, A. U.; Pandey, Jiten; Majumdar, Anjali
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 5 p. 481 - 483
