1: butyllithium / tetrahydrofuran; hexane / 2 h / -100 °C 2: 81 percent / butylllithium / tetrahydrofuran; hexane View Scheme

1: 2-bromo-1-iodo-4-(trifluoromethyl)benzene With isopropylmagnesium chloride in tetrahydrofuran T=-78°C; Inert atmosphere; 2: N,N-dimethyl-formamide in tetrahydrofuran T=-78 - 20°C; Inert atmosphere;

1: With n-butyllithium; tetramethylpiperidine in tetrahydrofuran; hexane T=-100°C; 2 h; 2: With iodine in tetrahydrofuran; hexane Further stages.;

1: With hydrogenchloride; sulfuric acid in water Cooling with ice; 2: With sodium nitrite in water T=0°C; 0.5 h; 3: With potassium iodide in water T=0 - 20°C;

n-butyllithium in tetrahydrofuran; hexane T=-100°C; 2 h;