1-甲基-5-三氟甲基-3-吡唑羧酸合成路线 （共 7 条）
反应条件
ruthenium trichloride; sodium periodate in tetrachloromethane; water; acetonitrile T=20°C; 0.0833333 h;
参考文献
Fustero, Santos; Roman, Raquel; Sanz-Cervera, Juan F.; Simon-Fuentes, Antonio; Cunat, Ana C.; Villanova, Salvador; Murguia, Marcelo
Journal of Organic Chemistry, 2008 , vol. 73, # 9 p. 3523 - 3529
反应条件
sodium hydroxide; zinc in water T=25°C; 1 h;
参考文献
Schlosser, Manfred; Volle, Jean-Noel; Leroux, Frederic; Schenk, Kurt
European Journal of Organic Chemistry, 2002 , # 17 p. 2913 - 2920
反应条件
1: 1-methyl-5-(trifluoromethyl)pyrazole With lithium diisopropyl amide in tetrahydrofuran; hexane T=-75°C; 0.75 h; 2: carbon dioxide Further stages.;
参考文献
Schlosser, Manfred; Volle, Jean-Noel; Leroux, Frederic; Schenk, Kurt
European Journal of Organic Chemistry, 2002 , # 17 p. 2913 - 2920
反应条件
1: 67 percent / bromine; iron powder / 1 h / 100 °C 2: 70 percent / diisopropylamine; butyllithium / tetrahydrofuran; hexane / 0.08 h / -75 °C 3: 93 percent / zinc; NaOH / H2O / 1 h / 25 °C View Scheme
参考文献
Schlosser, Manfred; Volle, Jean-Noel; Leroux, Frederic; Schenk, Kurt
European Journal of Organic Chemistry, 2002 , # 17 p. 2913 - 2920
反应条件
1: 70 percent / diisopropylamine; butyllithium / tetrahydrofuran; hexane / 0.08 h / -75 °C 2: 93 percent / zinc; NaOH / H2O / 1 h / 25 °C View Scheme
参考文献
Schlosser, Manfred; Volle, Jean-Noel; Leroux, Frederic; Schenk, Kurt
European Journal of Organic Chemistry, 2002 , # 17 p. 2913 - 2920
反应条件
1.1: ethanol / 1 h / 0 - 20 °C 2.1: hydrogenchloride / water; tetrahydrofuran / 0.5 h / Reflux 3.1: potassium permanganate / water; acetone / 4 h / 60 °C 3.2: 20 °C View Scheme
参考文献
BAYER CROPSCIENCE AG; YONETA, Yasushi; ISHIKAWA, Koichi; SHIMOJO, Eiichi; ICHIHARA, Teruyuki; ATAKA, Masashi; SHIBUYA, Katsuhiko
Patent: WO2012/25460 A1, 2012 ;
反应条件
1.1: hydrogenchloride / water; tetrahydrofuran / 0.5 h / Reflux 2.1: potassium permanganate / water; acetone / 4 h / 60 °C 2.2: 20 °C View Scheme
参考文献
BAYER CROPSCIENCE AG; YONETA, Yasushi; ISHIKAWA, Koichi; SHIMOJO, Eiichi; ICHIHARA, Teruyuki; ATAKA, Masashi; SHIBUYA, Katsuhiko
Patent: WO2012/25460 A1, 2012 ;
