2-(2,4,6-trimethyl-phenyl)-2,5,6,7-tetrahydro-pyrrolo[2,1-c] [1,2,4]triazol-4-ylium perchlorate; (4aR,9aS)-6-bromo-4-hydroxy-4,4a,9,9a-tetrahydroindeno[2,1-b][1,4]oxazin-3(2H)-one; potassium carbonate in tetrahydrofuran T=23°C; 36 h;

1: With C42H58N4O2Ti in toluene T=110°C; 14 h; Inert atmosphereSchlenk technique; 2: With formic acid; [{(S,S)-Ts-dpen}(η6-p-cymene)RuCl]; triethylamine in N,N-dimethyl-formamide; toluene T=20°C; 14 h; Inert atmosphereSchlenk technique; enantioselective reaction;

in dichloromethane 48 h;

lithium aluminium tetrahydride in tetrahydrofuran T=25°C;

2-(2,4,6-trimethyl-phenyl)-2,5,6,7-tetrahydro-pyrrolo[2,1-c] [1,2,4]triazol-4-ylium perchlorate; (4aR,9aS)-4-hydroxy-4,4a,9,9a-tetrahydroindeno[2,1-b][1,4]oxazin-3(2H)-one; 1,8-diazabicyclo[5.4.0]undec-7-ene in dichloromethane T=23°C; 18 h; Inert atmosphereResolution of racemate; optical yield given as percent eeenantioselective reaction;

2-(2,4,6-trimethyl-phenyl)-2,5,6,7-tetrahydro-pyrrolo[2,1-c] [1,2,4]triazol-4-ylium perchlorate; (4aR,9aS)-6-bromo-4-hydroxy-4,4a,9,9a-tetrahydroindeno[2,1-b][1,4]oxazin-3(2H)-one; potassium carbonate in isopropanol acetate T=23°C; 24 h; Resolution of racemate;

in dichloromethane T=23°C; 48 h; aminomethyl polystyrene resin; Inert atmosphereResolution of racemate;

in dichloromethane T=23°C; 48 h; aminomethyl polystyrene resin; Inert atmosphereResolution of racemate;