5,6-二甲氧基-2-(4-吡啶甲基)-1-茚酮/多萘哌齐杂质B合成路线 （共 13 条）
反应条件
hydrogen; platinum(IV) oxide in acetic acid T=80°C; P=760.051 Torr; 6 h;
参考文献
TIAN JIN HEMAY BIO-TECH CO., LTD
Patent: US2007/72905 A1, 2007 ;
Location in patent: Page/Page column 5 ;
参考文献
JUBILANT ORGANOSYS LIMITED
Patent: WO2006/70396 A1, 2006 ;
Location in patent: Page/Page column 12 ;
反应条件
hydrogen; platinum(IV) oxide in methanol T=20°C; P=760.051 Torr; 10.5 h;
参考文献
Neu, Jozsef; Greiner, Istvan; Csabai, Janos; Garadnay, Sandor
Patent: US2008/306271 A1, 2008 ;
Location in patent: Page/Page column 7-8 ;
反应条件
hydrogen; platinum(IV) oxide in methanol T=20°C; P=760.051 Torr; 10.5 h;
参考文献
Neu, Jozsef; Greiner, Istvan; Csabai, Janos; Garadnay, Sandor
Patent: US2008/306271 A1, 2008 ;
Location in patent: Page/Page column 8 ;
反应条件
trifluorormethanesulfonic acid in nitromethane T=100°C; Friedel-Crafts acylation; 0.75 h;
参考文献
Fillion, Eric; Fishlock, Dan; Wilsily, Ashraf; Goll, Julie M.
Journal of Organic Chemistry, 2005 , vol. 70, # 4 p. 1316 - 1327
反应条件
in ethanol; water; ethyl acetate; N,N-dimethyl-formamide
参考文献
Eisai Co., Ltd.
Patent: US6252081 B1, 2001 ;
反应条件
hydrogen; acetic acid; palladium on activated charcoal in methanol T=60 - 65°C; 7 h;
参考文献
Elati, Chandrashekar R.; Kolla, Naveenkumar; Chalamala, Subrahmanyeswara Rao; Vankawala, Pravinchandra J.; Sundaram, Venkataraman; Vurimidi, Himabindu; Mathad, Vijayavitthal T.
Synthetic Communications, 2006 , vol. 36, # 2 p. 169 - 174
反应条件
1: 95.6 percent / p-toluenesulfonic acid / toluene / 6 h / Heating 2: hydrogen; acetic acid / palladium on activated charcoal / methanol / 7 h / 60 - 65 °C View Scheme
参考文献
Clark, John K.; Cowley, Phill; Muir, Alan W.; Palin, Ronald; Pow, Eleanor; Prosser, Alan B.; Taylor, Robert; Zhang, Ming-Qiang
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 18 p. 2565 - 2568
反应条件
1: 95.6 percent / p-toluenesulfonic acid / toluene / 6 h / Heating 2: hydrogen; acetic acid / palladium on activated charcoal / methanol / 7 h / 60 - 65 °C View Scheme
参考文献
Clark, John K.; Cowley, Phill; Muir, Alan W.; Palin, Ronald; Pow, Eleanor; Prosser, Alan B.; Taylor, Robert; Zhang, Ming-Qiang
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 18 p. 2565 - 2568
反应条件
1.1: piperidinium acetate / ethanol / 0.5 h 1.2: 77 percent / NaBH3CN / ethanol / 0 - 20 °C 2.1: 74 percent / K2CO3 / dimethylformamide 3.1: 77 percent / TfOH / nitromethane / 0.75 h / 100 °C View Scheme
参考文献
Fillion, Eric; Fishlock, Dan; Wilsily, Ashraf; Goll, Julie M.
Journal of Organic Chemistry, 2005 , vol. 70, # 4 p. 1316 - 1327
