6-(3,4-二甲氧基苯基)吡啶甲酸合成路线 （共 2 条）
反应条件
sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium(0) in water; toluene
T=90°C; Suzuki Coupling; 16 h;
参考文献
NEUROGEN CORPORATION
Patent: WO2006/15279 A1, 2006 ;
Location in patent: Page/Page column 46 ;
WO 2006/015279 A1
反应条件
sodium hydroxide in tetrahydrofuran; methanol; water
T=60°C; 0.5 h;
参考文献
YAMANOUCHI PHARMACEUTICAL CO. LTD.
Patent: EP1396487 A1, 2004 ;
Location in patent: Page 13 ;
