5-甲氧基吲哚-2-甲酸乙酯合成路线 （共 27 条）
反应条件
1: 80 percent / POCl3 2: 75 percent / 90percent hydrazine hydrate / 3 h / Heating 3: 80 percent / phosphorus pentasulfide, pyridine / 4 h / Heating 4: 75 percent / 90percent hydrazine hydrate / 5 h / Heating 5: 90 percent / 5 h / Heating View Scheme
参考文献
Monge; Parrado; Font; Fernandez-Alvarez
Journal of Medicinal Chemistry, 1987 , vol. 30, # 6 p. 1029 - 1035
反应条件
1: 80 percent / POCl3 2: 75 percent / 90percent hydrazine hydrate / 3 h / Heating 3: 80 percent / phosphorus pentasulfide, pyridine / 4 h / Heating 4: 75 percent / 90percent hydrazine hydrate / 5 h / Heating 5: 90 percent / ethanol / Heating View Scheme
参考文献
Monge; Parrado; Font; Fernandez-Alvarez
Journal of Medicinal Chemistry, 1987 , vol. 30, # 6 p. 1029 - 1035
反应条件
sodium hydroxide in ethanol Heating;
参考文献
Cruces, M. A.; Elorriaga, C.; Fernandez-Alvarez, E.; Lopez, O. Nieto
European Journal of Medicinal Chemistry, 1990 , vol. 25, # 3 p. 257 - 265
反应条件
1: 95 percent / K2CO3 / acetone / Heating 2: 85 percent / NaOH / ethanol / Heating View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 25, # 3 p. 257 - 265
反应条件
trichlorophosphate in N,N-dimethyl-formamide T=20°C; 3 h;
参考文献
Pagire, Haushabhau S.; Chun, Hang-Suk; Bae, Myung Ae; Ahn, Jin Hee
Tetrahedron, 2013 , vol. 69, # 14 p. 3039 - 3044
反应条件
trichlorophosphate T=20°C; Vilsmeier formylation;
参考文献
Lee, Jae Hong; So, Ju-Hoon; Jeon, Jong Hyun; Choi, Eun Bok; Lee, Yu-Ri; Chang, Young-Tae; Kim, Cheol-Hee; Bae, Myung Ae; Ahn, Jin Hee
Chemical Communications, 2011 , vol. 47, # 26 p. 7500 - 7502
反应条件
trichlorophosphate in 1,2-dichloro-ethane Vilsmeier-Haack reaction; Heating;
参考文献
Hickman; Sturino; Lachance
Tetrahedron Letters, 2000 , vol. 41, # 43 p. 8217 - 8220
反应条件
lithium aluminium tetrahydride in tetrahydrofuran; diethyl ether 1.5 h; Heating;
参考文献
Leon, P.; Garbay-Jaureguiberry, C.; Barsi, M. C.; Pecq, J. B. Le; Roques, B. P.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 11 p. 2074 - 2080
反应条件
1: 98 percent / LiAlH4 / diethyl ether; tetrahydrofuran / 1.5 h / Heating 2: 60 percent / CrO3, pyridine / CH2Cl2 / 19 h / Ambient temperature View Scheme
参考文献
Meyer; Kruse
Journal of Organic Chemistry, 1984 , vol. 49, # 17 p. 3195 - 3199
反应条件
sodium hydride 1.) DMSO, 50 deg C, 30 min, 2.) 80 deg C, 30 min; Yield given. Multistep reaction;
参考文献
Murakami; Watanabe; Kobayashi
Synthesis, 1984 , vol. NO. 9, p. 738 - 740
