5-羟基-6-甲基-3,4-吡啶二甲酸合成路线 （共 19 条）
反应条件
1: chlorobenzene; PCl5
2: SnCl2; concentrated aqueous HCl; acetic acid
3: palladium/BaSO4; ethanol / Hydrogenation
4: concentrated aqueous HCl
5: aqueous H2SO4; aqueous NaNO2 / 90 - 95 °C
View Scheme
参考文献
Ichiba; Emoto
Scientific Papers of the Institute of Physical and Chemical Research (Japan), 1941 , vol. 38, p. 347,350
反应条件
1: diethylamine; ethanol
2: urea; acetic acid anhydride; HNO3
3: chlorobenzene; PCl5
4: SnCl2; concentrated aqueous HCl; acetic acid
5: palladium/BaSO4; ethanol / Hydrogenation
6: concentrated aqueous HCl
7: aqueous H2SO4; aqueous NaNO2 / 90 - 95 °C
View Scheme
参考文献
Ichiba; Emoto
Scientific Papers of the Institute of Physical and Chemical Research (Japan), 1941 , vol. 38, p. 347,350
参考文献
Cohen et al.
Journal of the Chemical Society, 1952 , p. 4374,4380
Full Text Show Details
Hoffmann-La Roche
Patent: US2440218 , 1943 ;
参考文献
Cohen et al.
Journal of the Chemical Society, 1952 , p. 4374,4380
Full Text Show Details
Hoffmann-La Roche
Patent: US2440218 , 1943 ;
反应条件
1: concentrated aqueous HCl
2: aqueous H2SO4; aqueous NaNO2 / 90 - 95 °C
View Scheme
参考文献
Wuest et al.
Recueil des Travaux Chimiques des Pays-Bas, 1959 , vol. 78, p. 226,240
Full Text Show Details
Ichiba; Emoto
Scientific Papers of the Institute of Physical and Chemical Research (Japan), 1941 , vol. 38, p. 347,350
反应条件
1: palladium/BaSO4; ethanol / Hydrogenation
2: concentrated aqueous HCl
3: aqueous H2SO4; aqueous NaNO2 / 90 - 95 °C
View Scheme
参考文献
Wuest et al.
Recueil des Travaux Chimiques des Pays-Bas, 1959 , vol. 78, p. 226,240
Full Text Show Details
Ichiba; Emoto
Scientific Papers of the Institute of Physical and Chemical Research (Japan), 1941 , vol. 38, p. 347,350
反应条件
nicotinamide adenine dinucleotide in phosphate buffer
pH=8.0; Enzyme kinetics;
参考文献
Mukherjee, Tathagata; Kinsland, Cynthia; Begley, Tadhg P.
Bioorganic Chemistry, 2007 , vol. 35, # 6 p. 458 - 464
反应条件
1: ethanol / Erhitzen des vom Aethanol befreiten Reaktionsgemisches auf 115-125grad
2: lithium alanate; diethyl ether / 0 °C
View Scheme
参考文献
Wuest et al.
Recueil des Travaux Chimiques des Pays-Bas, 1959 , vol. 78, p. 226,240
反应条件
1: diethyl ether; methanol / -15 °C
2: lithium alanate; diethyl ether / 0 °C
View Scheme
参考文献
Wuest et al.
Recueil des Travaux Chimiques des Pays-Bas, 1959 , vol. 78, p. 226,240
