4-羟基-5-嘧啶甲酸乙酯合成路线 （共 6 条）
反应条件
hydrogenchloride in ethanol; water; ethyl acetate
参考文献
Corvas International, Inc.
Patent: US5656645 A1, 1997 ;
US 5656645 A
反应条件
in ethanol T=120°C; 15 h; Microwave irradiation;
参考文献
MERCK SHARP andamp; DOHME CORP.; KEENAN, Kevin, A.; NORTHRUP, Alan, B.
Patent: WO2010/65384 A1, 2010 ;
Location in patent: Page/Page column 30; 31 ;
反应条件
1: ethanolic sodium ethylate 2: aqueous H2SO4; aqueous H2O2 View Scheme
参考文献
Ballard; Johnson
Journal of the American Chemical Society, 1942 , vol. 64, p. 794,797
反应条件
sulfuric acid; dihydrogen peroxide
参考文献
Ballard; Johnson
Journal of the American Chemical Society, 1942 , vol. 64, p. 794,797
反应条件
sodium methylate in methanol 4 h;
参考文献
Scott, James S.; Gill, Adrian L.; Godfrey, Linda; Groombridge, Sam D.; Rees, Amanda; Revill, John; Schofield, Paul; Soerme, Pernilla; Stocker, Andrew; Swales, John G.; Whittamore, Paul R.O.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 21 p. 6756 - 6761
反应条件
thionyl chloride in tetrahydrofuran 4 h; Heating / reflux;
参考文献
BAYER PHARMACEUTICALS CORPORATION
Patent: WO2006/49681 A2, 2006 ;
Location in patent: Page/Page column 38 ;
WO 2006/049681 A2
