3-甲氧基-2-甲基-4H-吡喃-4-酮合成路线 （共 17 条）
反应条件
1: 77 percent / conc. ammonia / 3 h / 110 °C 2: 85 percent / POCl3 / 10 h / Heating View Scheme
参考文献
Kuhler; Fryklund; Bergman; Weilitz; Lee; Larsson
Journal of Medicinal Chemistry, 1995 , vol. 38, # 25 p. 4906 - 4916
参考文献
Peratoner; Tamburello
Gazzetta Chimica Italiana, 1906 , vol. 36 I, p. 43
Chem. Zentralbl., 1905 , vol. 76, # II p. 680
反应条件
1: 77 percent / conc. ammonia / 3 h / 110 °C 2: 85 percent / POCl3 / 10 h / Heating 3: NaOMe / 10 h / Heating 4: 98 percent / 84percent m-CPBA / CH2Cl2 / 4 h / Ambient temperature View Scheme
参考文献
Kuhler; Fryklund; Bergman; Weilitz; Lee; Larsson
Journal of Medicinal Chemistry, 1995 , vol. 38, # 25 p. 4906 - 4916
反应条件
ammonium hydroxide T=70°C;
参考文献
Ma, Yongmin; Luo, Wei; Quinn, Peter J.; Liu, Zudong; Hider, Robert C.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6349 - 6362
反应条件
1: 77 percent / conc. ammonia / 3 h / 110 °C 2: 85 percent / POCl3 / 10 h / Heating 3: NaOMe / 10 h / Heating 4: 98 percent / 84percent m-CPBA / CH2Cl2 / 4 h / Ambient temperature 5: 4 h / 100 °C 6: 2 M NaOH / 1 h / 100 °C 7: 100 percent / SOCl2 / CH2Cl2 / 2 h View Scheme
参考文献
Kuhler; Fryklund; Bergman; Weilitz; Lee; Larsson
Journal of Medicinal Chemistry, 1995 , vol. 38, # 25 p. 4906 - 4916
反应条件
1: 77 percent / conc. ammonia / 3 h / 110 °C 2: 85 percent / POCl3 / 10 h / Heating 3: NaOMe / 10 h / Heating 4: 98 percent / 84percent m-CPBA / CH2Cl2 / 4 h / Ambient temperature 5: 4 h / 100 °C 6: 2 M NaOH / 1 h / 100 °C View Scheme
参考文献
Kuhler; Fryklund; Bergman; Weilitz; Lee; Larsson
Journal of Medicinal Chemistry, 1995 , vol. 38, # 25 p. 4906 - 4916
反应条件
1: 80.5 percent / NH4OH / 1.) refluxm 12 h, 2.) room temperature, 4 h 2: 77 percent / 48percent HBr / 4 h / 140 - 150 °C View Scheme
参考文献
Hwang; Proctor; Driscoll
Journal of Pharmaceutical Sciences, 1980 , vol. 69, # 9 p. 1074 - 1076
反应条件
potassium hydroxide
cooling;
参考文献
Ma, Yongmin; Luo, Wei; Quinn, Peter J.; Liu, Zudong; Hider, Robert C.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6349 - 6362
反应条件
potassium carbonate in acetone
3 h; Inert atmosphereReflux;
参考文献
Ehrlich, Michael; Carell, Thomas
European Journal of Organic Chemistry, 2013 , # 1 p. 77 - 83
反应条件
potassium hydroxide in acetone
T=20°C; 12 h;
参考文献
Andayi, Warren A.; Egan, Timothy J.; Gut, Jiri; Rosenthal, Philip J.; Chibale, Kelly
ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 7 p. 642 - 646
