7-甲基-4-羟基-9-甲氧基-5H-呋喃并[3,2-g][1]苯并吡喃-5-酮合成路线 (共 8 条)
反应条件
potassium carbonate; acetone; methyl iodide
参考文献
Journal of the American Pharmaceutical Association (1912-1977), , vol. 41, p. 325
反应条件
potassium carbonate in acetonitrile
T=80°C; 1.5 h;
参考文献
HARVEY, Andrew, J.; BAELL, Jonathan, B.; WULFF, Heike
Patent: WO2006/96911 A1, 2006 ;
Location in patent: Page/Page column 41; 42 ;
WO 2006/096911 A1
反应条件
boron trichloride in dichloromethane
T=-78 - 20°C;
参考文献
Cianci, Julia; Baell, Jonathan B.; Flynn, Bernard L.; Gable, Robert, W.; Mould, Jorgen A.; Paul, Dharam; Harvey, Andrew J.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 6 p. 2055 - 2061
反应条件
potassium carbonate; methyl iodide; benzene
参考文献
Selleri; di Paco
Annali di Chimica (Rome, Italy), 1958 , vol. 48, p. 1205,1209
反应条件
in chloroform
48 h; Irradiation; Further byproducts given;
参考文献
Caffieri, Sergio; Favretto, Donata
Journal of Organic Chemistry, 1993 , vol. 58, # 25 p. 7059 - 7063
反应条件
1: aq. NaOH solution; pyridine; potassium peroxo disulfate / Reagens 4: Wasser, weit. Ang.: Erwaermen der nach dem Ansaeuern loeslichen Teile des Reaktionsgemisches mit wss. Salzsaeure und Natriumsulfit
2: acetone; methyl iodide; potassium carbonate
View Scheme
参考文献
Mukerjee; Seshadri
Proceedings - Indian Academy of Sciences, Section A, 1952 , # 35 p. 323,324
反应条件
in chloroform
48 h; Irradiationother solvents; Rate constantProduct distribution;
参考文献
Caffieri, Sergio; Favretto, Donata
Journal of Organic Chemistry, 1993 , vol. 58, # 25 p. 7059 - 7063
反应条件
1: 90 percent / cesium carbonate / dimethylformamide / 20 °C
2: 75 percent / aq. NaOH / ethanol / 3 h / 70 °C
View Scheme
参考文献
Harvey, Andrew J.; Baell, Jonathan B.; Toovey, Nathan; Homerick, Daniel; Wulff, Heike
Journal of Medicinal Chemistry, 2006 , vol. 49, # 4 p. 1433 - 1441