formic acid 60 h; Heating;

1: 1.) phosphorus oxychloride / 1.) RT, 30 min, 2.) 100 deg C, 2 h 2: 98 percent / sodium chlorite, dibasic sodium phosphate, 2-methyl-2-butene / 2-methyl-propan-2-ol; H2O / 0.5 h / Ambient temperature 3: 85 percent / nitric acid / 0.17 h / 0 °C 4: 95 percent / hydrogen / platinum oxide / 2 h / 2068.6 Torr 5: 78 percent / sodium hydroxide / toluene / 0 °C 6: 88 percent / sodium hydride / N,N-dimethyl-acetamide / 1.) RT, 12 h, 2.) 30 min 7: diisopropylamine, n-butyllithium / tetrahydrofuran; hexane / 1.) -78 deg C, 90 min, 2.) RT, 90 min 8: 28 percent / palladium-on-charcoal / xylene / 1 h / Heating View Scheme

1: 98 percent / sodium chlorite, dibasic sodium phosphate, 2-methyl-2-butene / 2-methyl-propan-2-ol; H2O / 0.5 h / Ambient temperature 2: 85 percent / nitric acid / 0.17 h / 0 °C 3: 95 percent / hydrogen / platinum oxide / 2 h / 2068.6 Torr 4: 78 percent / sodium hydroxide / toluene / 0 °C 5: 88 percent / sodium hydride / N,N-dimethyl-acetamide / 1.) RT, 12 h, 2.) 30 min 6: diisopropylamine, n-butyllithium / tetrahydrofuran; hexane / 1.) -78 deg C, 90 min, 2.) RT, 90 min 7: 28 percent / palladium-on-charcoal / xylene / 1 h / Heating View Scheme

1: 95 percent / hydrogen / platinum oxide / 2 h / 2068.6 Torr 2: 78 percent / sodium hydroxide / toluene / 0 °C 3: 88 percent / sodium hydride / N,N-dimethyl-acetamide / 1.) RT, 12 h, 2.) 30 min 4: diisopropylamine, n-butyllithium / tetrahydrofuran; hexane / 1.) -78 deg C, 90 min, 2.) RT, 90 min 5: 28 percent / palladium-on-charcoal / xylene / 1 h / Heating View Scheme

1: 85 percent / nitric acid / 0.17 h / 0 °C 2: 95 percent / hydrogen / platinum oxide / 2 h / 2068.6 Torr 3: 78 percent / sodium hydroxide / toluene / 0 °C 4: 88 percent / sodium hydride / N,N-dimethyl-acetamide / 1.) RT, 12 h, 2.) 30 min 5: diisopropylamine, n-butyllithium / tetrahydrofuran; hexane / 1.) -78 deg C, 90 min, 2.) RT, 90 min 6: 28 percent / palladium-on-charcoal / xylene / 1 h / Heating View Scheme

1: 78 percent / sodium hydroxide / toluene / 0 °C 2: 88 percent / sodium hydride / N,N-dimethyl-acetamide / 1.) RT, 12 h, 2.) 30 min 3: diisopropylamine, n-butyllithium / tetrahydrofuran; hexane / 1.) -78 deg C, 90 min, 2.) RT, 90 min 4: 28 percent / palladium-on-charcoal / xylene / 1 h / Heating View Scheme

1: 88 percent / sodium hydride / N,N-dimethyl-acetamide / 1.) RT, 12 h, 2.) 30 min 2: diisopropylamine, n-butyllithium / tetrahydrofuran; hexane / 1.) -78 deg C, 90 min, 2.) RT, 90 min 3: 28 percent / palladium-on-charcoal / xylene / 1 h / Heating View Scheme

1: diisopropylamine, n-butyllithium / tetrahydrofuran; hexane / 1.) -78 deg C, 90 min, 2.) RT, 90 min 2: 28 percent / palladium-on-charcoal / xylene / 1 h / Heating View Scheme

palladium on activated charcoal in xylene 1 h; Heating;

1: POCl3 / Heating 2: aq.HCl / Heating 3: K2CO3 / acetone / Heating View Scheme