4-(4-氯-6-(2-(二氟甲基)-1H-苯并[d]咪唑-1-基)-1,3,5-三嗪-2-基)吗啉合成路线 （共 3 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 4 h;
参考文献
US2007/244110 A1, ;
Page/Page column 4 ;
反应条件
1: 4,6-dichloro-N-morpholinyl-1,3,5-triazine-2-amine; 2-(difluoromethyl)-1H-benzo[d]imidazole With potassium carbonate in DMF (N,N-dimethyl-formamide) T=20°C; 16 h; 2: 2,4,6-trichloro-pyrimidine in DMF (N,N-dimethyl-formamide) T=20°C; 1.5 h;
参考文献
EP1389617 A1, ;
Page 12 ;
反应条件
1: water / 130 °C / |Sealed tube; |Microwave irradiation 2: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C View Scheme
参考文献
ACS Medicinal Chemistry Letters, , vol. 4, # 2 p. 206 - 210
WO2014/5182 A1, ;
