4,6,7,8-四氢-噻吩并[3,2-b]氮杂卓-5-酮合成路线 (共 7 条)
反应条件
potassium acetate in ethanol Rearrangement;
参考文献
Albright, J. Donald; Santos, Efren G. Delos; Dusza, John P.; Chan, Peter S.; Coupet, Joseph; Ru, Xun; Mazandarani
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 8 p. 695 - 698
反应条件
P2O5; methanesulfonic acid T=100 - 110°C; 5 h;
参考文献
Royer,R. et al.
European Journal of Medicinal Chemistry, 1976 , vol. 11, p. 221 - 224
参考文献
Albright, J. Donald; Santos, Efren G. Delos; Dusza, John P.; Chan, Peter S.; Coupet, Joseph; Ru, Xun; Mazandarani
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 8 p. 695 - 698
反应条件
1: 99 percent / NH2OH*HCl; aq. NaOAc / ethanol 2: 92 percent / pyridine 3: 60 percent / aq. KOAc / ethanol View Scheme
参考文献
Cho, Hidetsura; Murakami, Kengo; Nakanishi, Hiroyuki; Isoshima, Hirotaka; Hayakawa, Kazuhide; Uchida, Itsuo
Heterocycles, 1998 , vol. 48, # 5 p. 919 - 927
反应条件
sodium hydroxide in tetrahydrofuran; methanol
参考文献
American Cyanamid Company
Patent: US5654297 A1, 1997 ;
US 5654297 A
反应条件
dimethylsulfide borane complex in tetrahydrofuran Reduction;
参考文献
Albright, J. Donald; Santos, Efren G. Delos; Dusza, John P.; Chan, Peter S.; Coupet, Joseph; Ru, Xun; Mazandarani
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 8 p. 695 - 698
参考文献
Royer,R. et al.
European Journal of Medicinal Chemistry, 1976 , vol. 11, p. 221 - 224