4-[(3-氨基丙基)氨基]丁腈合成路线 （共 5 条）
反应条件
1: 84 percent / Et3N / dioxane; H2O / 72 h / 23 °C 2: 82 percent / hydrogen, NaOH / Raney Ni / ethanol; H2O / 2625.2 Torr View Scheme
参考文献
Helvetica Chimica Acta, , vol. 77, # 5 p. 1229 - 1235
反应条件
1: With N-ethyl-N,N-diisopropylamine in dichloromethane 2: With lithium aluminium tetrahydride in diethyl ether
参考文献
US2008/255213 A1, ;
Page/Page column 5; sheet 6 ;
反应条件
ammonia; hydrogen; nickel in ethanol
参考文献
Israel,M. et al.
J. Med. Chem., 1964 , vol. 7, p. 710 - 716
反应条件
in methanol
T=20°C; 8 h;
参考文献
Detterbeck, Richard; Guggisberg, Armin; Popaj, Kasim; Hesse, Manfred
Helvetica Chimica Acta, 2002 , vol. 85, # 6 p. 1742 - 1758
参考文献
Magainin Pharmaceuticals, Inc.
Patent: US5792635 A1, 1998 ;
