1,4-环己二酮单乙二醇缩酮合成路线 （共 270 条）
反应条件
sodium tris(acetoxy)borohydride in 1,2-dichloro-ethane 4 h; Ambient temperature;
参考文献
AVENTIS PHARMA DEUTSCHLAND GMBH
Patent: WO2005/70898 A1, 2005 ;
Location in patent: Page/Page column 44 ;
WO 2005/070898 A1
反应条件
1: 98 percent / toluene / Heating 2: 83 percent / ethane-1,2-diol / 4 h / 180 °C 3: 76 percent / aq. HCl / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
Busto, Eduardo; Gotor-Fernandez, Vicente; Gotor, Vicente
Journal of Organic Chemistry, 2012 , vol. 77, # 10 p. 4842 - 4848
反应条件
hydrogenchloride; triethylamine in water; 1,2-dichloro-ethane
参考文献
Takeda Chemical Industries, Ltd.
Patent: US6096780 A1, 2000 ;
US 6096780 A
反应条件
triethylamine in water; 1,2-dichloro-ethane
参考文献
Takeda Chemical Industries, Ltd.
Patent: US6166006 A1, 2000 ;
US 6166006 A
反应条件
1: glacial acetic acid; sodium triacetoxyborohydride / CH2Cl2; tetrahydrofuran / 10 - 20 °C 2: 119 g / hydrochloric acid / H2O / 1 h / Heating View Scheme
参考文献
Deskus, Jeffrey A.; Epperson, James R.; Sloan, Charles P.; Cipollina, Joseph A.; Dextraze, Pierre; Qian-Cutrone, Jingfang; Gao, Qi; Ma, Baoqing; Beno, Brett R.; Mattson, Gail K.; Molski, Thaddeus F.; Krause, Rudolph G.; Taber, Matthew T.; Lodge, Nicholas J.; Mattson, Ronald J.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 11 p. 3099 - 3104
反应条件
1: tetrahydrofuran / 3 h / 10 - 20 °C 2: trifluoroacetic acid / dichloromethane / 5 h / 20 °C 3: palladium 10 on activated carbon; hydrogen / ethyl acetate / 16 h / 20 °C View Scheme
参考文献
Ekkati, Anil R.; Mandiyan, Valsan; Ravindranathan, Krishna P.; Bae, Jae H.; Schlessinger, Joseph; Jorgensen, William L.
Tetrahedron Letters, 2011 , vol. 52, # 17 p. 2228 - 2231
反应条件
1: 85 percent / Zn / benzene / 1.5 h / 20 °C / Heating 2: 80 percent / LiAlH / diethyl ether / 2.8 h / 20 °C / Heating 3: water; Dowex 50X8-100 (H+ form) / 24 h / 20 °C 4: 47 percent / p-TsOH / 2 h / 20 °C View Scheme
参考文献
Soriente, Annunziata; Della Rocca, Anna; Sodano, Guido; Trincone, Antonio
Tetrahedron, 1997 , vol. 53, # 13 p. 4693 - 4702
反应条件
1.1: methanol-d1 / 2 h / 20 °C 1.2: 18 h / 25 - 30 °C / pH Ca. 6 2.1: sulfuric acid / water / 95 - 100 °C View Scheme
参考文献
Nirogi, Ramakrishna V. S.; Konda, Jagadishu Babu; Kambhampati, Ramasastry; Shinde, Anil; Bandyala, Thrinath Reddy; Gudla, Parandhama; Kandukuri, Kiran Kumar; Jayarajan, Pradeep; Kandikere, Vishwottam; Dubey, P. K.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 22 p. 6980 - 6985,6
反应条件
1.1: NaBH4 / methanol / 3 h / 0 °C 2.1: KH / tetrahydrofuran / 1 h / 0 °C 2.2: 96 percent / tetrahydrofuran / 0 - 20 °C 3.1: 92 percent / PPTS; H2O / acetone / 5.5 h / Heating View Scheme
参考文献
Spino, Claude; Hill, Bryan; Dube, Pascal; Gingras, Stephane
Canadian Journal of Chemistry, 2003 , vol. 81, # 1 p. 81 - 108
反应条件
1: isopropyl-triphenyl-phosphonium iodide With sodium hydride in dimethyl sulfoxide; mineral oil T=50°C; Wittig Reaction; 0.75 h; Inert atmosphere; 2: 1,4-cyclohexanedione monoacetal in dimethyl sulfoxide; mineral oil T=50°C; Wittig Reaction; 16.75 h;
参考文献
NEO ONCOLOGY INC.; CHEN, Thomas; LEVIN, Daniel; PUPPALI, Satish; DICKMAN, Daniel, A.
Patent: WO2012/83178 A1, 2012 ;
Location in patent: Page/Page column 35-36 ;
