5-甲氧基-1(3h)-异苯并呋喃酮合成路线 （共 19 条）
反应条件
4-(N,N-dimethlyamino)pyridine; 1,1'-bis-(diphenylphosphino)ferrocene; N-ethyl-N,N-diisopropylamine; palladium diacetate in 1,4-dioxane
T=180°C; 0.5 h; microwave irradiation;
参考文献
Wu, Xiongyu; Mahalingam; Wan, Yiqian; Alterman, Mathias
Tetrahedron Letters, 2004 , vol. 45, # 24 p. 4635 - 4638
反应条件
palladium diacetate; potassium hydrogencarbonate
T=140°C; 18 h; Sealed tube;
参考文献
Teixeira; Pereira; Da Silva; Guilardi; Paixao; Anconi; De Almeida; Ellena; Forlani
Journal of Molecular Structure, 2014 , vol. 1061, # 1 p. 61 - 68
反应条件
palladium diacetate; potassium hydrogencarbonate
T=140°C; 36 h;
参考文献
Zhang, Yang-Hui; Shi, Bing-Feng; Yu, Jin-Quan
Angewandte Chemie, International Edition, 2009 , vol. 48, # 33 p. 6097 - 6100
Angewandte Chemie, 2009 , vol. 121, # 33 p. 6213 - 6216
反应条件
hydrogenchloride
1.) room temperature, 3 d, 2.) reflux, 2 min;
参考文献
Epsztajn, Jan; Jozwiak, Andrzej; Szczesniak, Aleksandra K.
Tetrahedron, 1993 , vol. 49, # 4 p. 929 - 938
反应条件
tetrakis(triphenylphosphine) palladium(0)
参考文献
Dang, Qun; Brown, Brian S.; Van Poelje, Paul D.; Colby, Timothy J.; Erion, Mark D.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 11 p. 1505 - 1510
反应条件
magnesium oxide; trifluoroacetic acid; lithium chloride; palladium dichloride; Tl(OCOCF3)3
1.) THF, 25 deg C, 15 min, 2.) MeOH, room temperature, overnight; Yield given. Multistep reaction;
参考文献
Larock, Richard C.; Fellows, Constance A.
Journal of the American Chemical Society, 1982 , vol. 104, # 7 p. 1900 - 1907
反应条件
1: 72 percent / s-BuLi; TMEDA / tetrahydrofuran / 2 h / -40 °C
2: 74 percent / p-TsOH / toluene / 9 h / Heating
View Scheme
参考文献
Davis, Franklin A.; Andemichael, Yemane W.
Journal of Organic Chemistry, 1999 , vol. 64, # 23 p. 8627 - 8634
反应条件
hydrogenchloride; lithium hydroxide; copper; zinc
1.) water, boiling, 1 h, 2.) pH 1; Yield given. Multistep reaction;
参考文献
Epsztajn, Jan; Jozwiak, Andrzej; Szczesniak, Aleksandra K.
Tetrahedron, 1993 , vol. 49, # 4 p. 929 - 938
反应条件
Tl(OOCCF3)2; magnesium oxide; lithium chloride; palladium dichloride
1)Tl(OOCCF3)2/CF3COOH,r.t.,overnight 2)PdCl2/MgO/LiCl/MeOH,r.t.,overnight; Yield given. Multistep reaction;
参考文献
Larock, Richard C.; Fellows, Constance A.
Journal of Organic Chemistry, 1980 , vol. 45, # 2 p. 363 - 365
反应条件
1: 1.) n-BuLi / 1.) THF, a) -78 deg C, 0.5 h, b) -> 0 deg C, 2 h, c) 0.1 h, 2.) a) -78 deg C, 1 h, b) room temperature, 1 h
2: 1.) Zn-Cu, LiOH*H2O, 2.) hydrochloric acid / 1.) water, boiling, 1 h, 2.) pH 1
View Scheme
参考文献
Epsztajn, Jan; Jozwiak, Andrzej; Szczesniak, Aleksandra K.
Tetrahedron, 1993 , vol. 49, # 4 p. 929 - 938
