呋喃并[3,4-c]吡啶-1(3h)-酮合成路线 （共 10 条）
反应条件
dicyclohexyl-carbodiimide in tetrahydrofuran; water
T=20°C; 19 h; Yield given;
参考文献
Ashcroft, William R.; Beal, Michael G.; Joule, John A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 3012 - 3015
反应条件
hydrogenchloride
72 h; Ambient temperature;
参考文献
Epsztajn; Jozwiak; Szczesniak
Synthetic Communications, 1994 , vol. 24, # 13 p. 1789 - 1798
反应条件
lithium aluminium tetrahydride in diethyl ether
3 h;
参考文献
Kuthan,J. et al.
Collection of Czechoslovak Chemical Communications, 1977 , vol. 42, p. 283 - 291
反应条件
hydrogenchloride; sodium tetrahydroborate
1) DMF, 2) reflux; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Orlek, Barry S.; Wadsworth, Harry; Wyman, Paul; Hadley, Michael S.
Tetrahedron Letters, 1991 , vol. 32, # 9 p. 1241 - 1244
反应条件
1: 1.) n-BuLi / 1.) THF, a) -78 deg C, 0.5 h, b) 0 deg C, 0.1 h, 2.) THF, a) -78 deg C, 1 h, b) 0 deg C, 1 h
2: 85 percent / KBH4 / methanol / Ambient temperature
3: 68 percent / 15percent aq. HCl / 72 h / Ambient temperature
View Scheme
参考文献
Epsztajn; Jozwiak; Szczesniak
Synthetic Communications, 1994 , vol. 24, # 13 p. 1789 - 1798
反应条件
1: 4.9 g / lithium aluminium hydride / tetrahydrofuran / 0.1 h / 0 - 2 °C
2: dicyclohexylcarbodi-imide / H2O; tetrahydrofuran / 19 h / 20 °C
View Scheme
参考文献
Ashcroft, William R.; Beal, Michael G.; Joule, John A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 3012 - 3015
反应条件
1: 5.3 g / sodium hydroxide, water / 1.5 h / 20 °C
2: 4.9 g / lithium aluminium hydride / tetrahydrofuran / 0.1 h / 0 - 2 °C
3: dicyclohexylcarbodi-imide / H2O; tetrahydrofuran / 19 h / 20 °C
View Scheme
参考文献
Ashcroft, William R.; Beal, Michael G.; Joule, John A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 3012 - 3015
反应条件
iron(II) trifluoromethanesulfonate; 2-((4R,5R)-1-((4-(tert-butyl)phenyl)sulfonyl)-4,5-diphenylimidazolidin-2-yl)-6-((4R,5R)-1-((4-(tert-butyl)phenyl)sulfonyl)-4,5-diphenylimidazolidin-2-yl)pyridine; oxygen
T=60°C; P=760.051 Torr; 16 h; Green chemistry; Catalytic behavior; regioselective reaction;
参考文献
Gonzalez-De-Castro, Angela; Robertson, Craig M.; Xiao, Jianliang
Journal of the American Chemical Society, 2014 , vol. 136, # 23 p. 8350 - 8360
反应条件
(alkaline solution);
参考文献
Queguiner,G.; Godard,A.
Comptes Rendus des Seances de l'Academie des Sciences, Serie C: Sciences Chimiques, 1969 , vol. 269, p. 1646 - 1649
反应条件
(i) NaBH4, (ii) H2SO4, MeOH; Multistep reaction;
参考文献
Coffen,D.L.; McEntee,T.E.
Journal of the Chemical Society [Section] D: Chemical Communications, 1971 , p. 539
