1-(4-碘苯基)-3-吗啉基-5,6-二氢吡啶-2(1H)-酮合成路线

Pinto, Donald J. P.; Orwat, Michael J.; Koch, Stephanie; Rossi, Karen A.; Alexander, Richard S.; Smallwood, Angela; Wong, Paneras C.; Rendina, Alan R.; Luettgen, Joseph M.; Knabb, Robert M.; He, Kan; Xin, Baomin; Wexler, Ruth R.; Lam, Patrick Y. S.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 22 p. 5339 - 5356

473927-69-41-(4-碘苯基)-3-吗啉基-5,6-二氢吡啶-2(1H)-酮+27143-07-3[(4-甲氧基苯基)肼基]氯乙酸乙酯→473927-64-96-(4-碘苯基)-1-(4-甲氧基苯基)-7-氧代-4,5,6,7-四氢-1H-吡唑并[3,4-c]吡啶-3-羧酸

参考文献

ZENTIVA, K.S.; HEJTMANKOVA, Ludmila; JIRMAN, Josef
Patent: WO2014/75648 A1, 2014 ;
Location in patent: Page/Page column 11 ;

473927-69-41-(4-碘苯基)-3-吗啉基-5,6-二氢吡啶-2(1H)-酮→473927-64-96-(4-碘苯基)-1-(4-甲氧基苯基)-7-氧代-4,5,6,7-四氢-1H-吡唑并[3,4-c]吡啶-3-羧酸

参考文献

Zhou, Jiacheng; Oh, Lynette M.; Ma, Philip; Li, Hui-Yin; Confalone, Pasquale
Patent: US2003/181466 A1, 2003 ;

473927-69-41-(4-碘苯基)-3-吗啉基-5,6-二氢吡啶-2(1H)-酮→503614-92-41-(4-甲氧基苯基)-7-氧代-6-[4-(2-氧代哌啶-1-基)苯基]-4,5,6,7-四氢-1H-吡唑并[3,4-c]吡啶-3-羧酸

参考文献

ZENTIVA, K.S.; HEJTMANKOVA, Ludmila; JIRMAN, Josef
Patent: WO2014/75648 A1, 2014 ;