N-羟基-1,3-苯并二氧戊环-5-甲脒合成路线 （共 8 条）
反应条件
hydroxylamine hydrochloride; sodium carbonate in ethanol T=80°C; 5 h;
参考文献
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; WANG, Rong; LU, Hongtao
Patent: WO2013/107336 A1, 2013 ;
Location in patent: Page/Page column 17 ;
反应条件
1: alcohol; water; hydroxylamine 2: acetic acid anhydride 3: alcohol; hydroxylamine / 60 °C View Scheme
参考文献
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; WANG, Rong; LU, Hongtao
Patent: WO2013/107336 A1, 2013 ;
反应条件
1: benzene; aqueous ammonia 2: phosphorus (V)-chloride 3: ethanol; sodium carbonate; water; hydroxylamine hydrochloride View Scheme
参考文献
Andrewes; King; Walker
Proceedings of the Royal Society of London, Series B: Biological Sciences, 1946 , vol. 133, p. 20,30
反应条件
1: phosphorus (V)-chloride 2: ethanol; sodium carbonate; water; hydroxylamine hydrochloride View Scheme
参考文献
Andrewes; King; Walker
Proceedings of the Royal Society of London, Series B: Biological Sciences, 1946 , vol. 133, p. 20,30
反应条件
1: acetic acid anhydride 2: alcohol; hydroxylamine / 60 °C View Scheme
参考文献
Marcus
Chemische Berichte, 1891 , vol. 24, p. 3652
反应条件
1.1: 1,1'-carbonyldiimidazole / acetonitrile / 1 h / 20 °C 1.2: 12 h / 20 °C 2.1: N,N-dimethyl-formamide / 3 h / 120 - 125 °C View Scheme
参考文献
Konyushkin; Godovikova; Vorontsova; Tsyganov; Karmanova; Raihstat; Firgang; Pokrovskii; Semenova; Semenov
Russian Chemical Bulletin, 2010 , vol. 59, # 12 p. 2268 - 2275
反应条件
laengere Beruehrung mit der Mutterlauge;
参考文献
Annales de Chimie (Cachan, France), , vol. <9> 16, p. 120
反应条件
pyridine in chloroform
T=20°C; 5.5 h; Reflux;
参考文献
Koryakova, Angela G.; Ivanenkov, Yan A.; Ryzhova, Elena A.; Bulanova, Elena A.; Karapetian, Ruben N.; Mikitas, Olga V.; Katrukha, Eugeny A.; Kazey, Vasily I.; Okun, Ilya; Kravchenko, Dmitry V.; Lavrovsky, Yan V.; Korzinov, Oleg M.; Ivachtchenko, Alexandre V.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 12 p. 3661 - 3666
