1.1: hydrogenchloride / water; acetone / 3.16 h / 20 °C / Inert atmosphere 2.1: immobilized lipase PS (pseudomonas cepacia) / ethyl acetate / 20 °C / Inert atmosphere 3.1: potassium hydroxide / dichloromethane; methanol / 2 h / 0 °C / Inert atmosphere 3.2: pH 5 4.1: toluene / 1.5 h / -20 °C / Inert atmosphere 5.1: methanol / 0 - 20 °C 6.1: (+/-)-2-Ethyloxirane / ethanol / Reflux; Inert atmosphere View Scheme

triethylsilane; trifluoroacetic acid in dichloromethane T=20°C; 2.5 h; Product distribution / selectivity;

1: potassium hydroxide / methanol; dichloromethane / 2 h / 0 °C 2: tetrahydrofuran; toluene / 1.5 h / -20 °C / Inert atmosphere 3: methanol; water / 0 - 20 °C 4: (+/-)-2-Ethyloxirane / ethanol / 6 h / Inert atmosphere; Reflux View Scheme

1: tetrahydrofuran; toluene / 1.5 h / -20 °C / Inert atmosphere 2: methanol; water / 0 - 20 °C 3: (+/-)-2-Ethyloxirane / ethanol / 6 h / Inert atmosphere; Reflux View Scheme

1: potassium hydroxide / tetrahydrofuran; methanol / 1 h / 50 °C / Inert atmosphere 2: immobilized lipase Pseudomonas cepacia / ethyl acetate / 20 h / 20 °C / Inert atmosphere; Enzymatic reaction 3: potassium hydroxide / methanol; dichloromethane / 2 h / 0 °C 4: tetrahydrofuran; toluene / 1.5 h / -20 °C / Inert atmosphere 5: methanol; water / 0 - 20 °C 6: (+/-)-2-Ethyloxirane / ethanol / 6 h / Inert atmosphere; Reflux View Scheme

1: immobilized lipase Pseudomonas cepacia / ethyl acetate / 20 h / 20 °C / Inert atmosphere; Enzymatic reaction 2: potassium hydroxide / methanol; dichloromethane / 2 h / 0 °C 3: tetrahydrofuran; toluene / 1.5 h / -20 °C / Inert atmosphere 4: methanol; water / 0 - 20 °C 5: (+/-)-2-Ethyloxirane / ethanol / 6 h / Inert atmosphere; Reflux View Scheme

potassium hydroxide