1,3-丙二醇，2 - （羟甲基）- 2 -苯基合成路线 （共 10 条）
反应条件
1: 51 percent / diethyl carbonate; KOH / 5 h / 95 - 100 °C 2: 94 percent / aq. NaOH / tetrahydrofuran / 2.5 h / 20 °C 3: 58 percent / dimethylformamide / 2 h / 80 °C 4: 54 percent / hydrazine hydrate / ethanol / 3 h / Heating View Scheme
参考文献
Kanoh, Shigeyoshi; Nishimura, Tomonari; Naka, Masashi; Motoi, Masatoshi
Tetrahedron, 2002 , vol. 58, # 35 p. 7065 - 7074
反应条件
pyridine; trichlorophosphate in diethyl ether
参考文献
Cooper; Lawston; Rickard; Inch
European Journal of Medicinal Chemistry, 1978 , vol. 13, # 3 p. 207 - 212
反应条件
potassium hydroxide; carbonic acid diethyl ester T=95 - 100°C; 5 h;
参考文献
Kanoh, Shigeyoshi; Nishimura, Tomonari; Naka, Masashi; Motoi, Masatoshi
Tetrahedron, 2002 , vol. 58, # 35 p. 7065 - 7074
反应条件
calcium hydroxide powder in tetrahydrofuran
T=60 - 65°C; 96 h;
参考文献
Hellmann, Konrad W.; Friedrich, Stefan; Gade, Lutz H.; Li, Wan-Sheung; McPartlin, Mary
Chemische Berichte, 1995 , vol. 128, # 1 p. 29 - 34
反应条件
hydrogen; palladium on activated charcoal in ethanol
2 h; Ambient temperature;
参考文献
Janssen, Bernd C.; Sernau, Volker; Huttner, Gottfried; Asam, Alexander; Walter, Olaf; et al.
Chemische Berichte, 1995 , vol. 128, # 1 p. 63 - 70
反应条件
1: LiAlH4 / diethyl ether / 2 h / Heating
2: H2 / Pd-C / ethanol / 760 Torr / Ambient temperature
View Scheme
参考文献
Cooper; Lawston; Rickard; Inch
European Journal of Medicinal Chemistry, 1978 , vol. 13, # 3 p. 207 - 212
反应条件
1: (i) Na, dioxane, (ii) /BRN= 1364034/
2: LiAlH4 / diethyl ether / 2 h / Heating
3: H2 / Pd-C / ethanol / 760 Torr / Ambient temperature
View Scheme
参考文献
Cooper; Lawston; Rickard; Inch
European Journal of Medicinal Chemistry, 1978 , vol. 13, # 3 p. 207 - 212
反应条件
sodium hydroxide in dichloromethane; water
T=10 - 20°C;
参考文献
Dupuy; Viguier; Dupraz
Synthetic Communications, 2001 , vol. 31, # 9 p. 1307 - 1313
反应条件
1: 51 percent / diethyl carbonate; KOH / 5 h / 95 - 100 °C
2: 69 percent / Et3N / CH2Cl2 / 5 h / 20 °C
3: 72 percent / TfOH / chlorobenzene / 0.17 h / 80 °C
View Scheme
参考文献
Kanoh, Shigeyoshi; Nishimura, Tomonari; Naka, Masashi; Motoi, Masatoshi
Tetrahedron, 2002 , vol. 58, # 35 p. 7065 - 7074
反应条件
1: 51 percent / diethyl carbonate; KOH / 5 h / 95 - 100 °C
2: 69 percent / Et3N / CH2Cl2 / 5 h / 20 °C
View Scheme
参考文献
Kanoh, Shigeyoshi; Nishimura, Tomonari; Naka, Masashi; Motoi, Masatoshi
Tetrahedron, 2002 , vol. 58, # 35 p. 7065 - 7074
