(E)-3,7-二甲基-2,6-辛二烯酸合成路线 （共 23 条）
反应条件
1: oxalyl chloride / benzene / a) 25 deg C, 2 h, b) 45 deg C, 30 min 2: 43 percent / Et3N / toluene / 3 h / Heating View Scheme
参考文献
Kulkarni, Yashwant S.; Niwa, Maho; Ron, Eyal; Snider, Barry B.
Journal of Organic Chemistry, 1987 , vol. 52, # 8 p. 1568 - 1576
反应条件
1: oxalyl chloride / benzene / a) 25 deg C, 2 h, b) 45 deg C, 30 min 2: 43 percent / Et3N / toluene / 3 h / Heating 3: 22 percent / NaOAc, Ac2O, AcOH / 12 h / Heating View Scheme
参考文献
Kulkarni, Yashwant S.; Niwa, Maho; Ron, Eyal; Snider, Barry B.
Journal of Organic Chemistry, 1987 , vol. 52, # 8 p. 1568 - 1576
参考文献
Beereboom,J.J.
Journal of Organic Chemistry, 1965 , vol. 30, p. 4230 - 4234
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Balant et al.
Helvetica Chimica Acta, 1951 , vol. 34, p. 722,726
反应条件
1: 82 percent / phosphate acid / toluene / 2 h / 100 °C 2: 91 percent / K2CO3 / acetone / 5 h / 20 °C 3: 85 percent / LiAlH4 / diethyl ether / 4 h / 20 °C 4: 55 percent / pyridine chromium trioxide chloride / CH2Cl2 / 4 h / 20 °C View Scheme
参考文献
Xiong, Yi; Wang, Kuiwu; Pan, Yuanjiang; Sun, Hongxiang; Tu, Jue
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 4 p. 786 - 789
反应条件
hydrogen; Rult;(R)-2,2'-bis(diphenylphosphino)-1,1'-binaphthylgt;(OCOCH3)2 in methanol T=15 - 30°C; P=76760.1 Torr; 12 h; Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 52, # 14 p. 3174 - 3176
反应条件
1: 82 percent / phosphate acid / toluene / 2 h / 100 °C 2: 91 percent / K2CO3 / acetone / 5 h / 20 °C View Scheme
参考文献
Nicolaou; Nilewski, Christian; Hale, Christopher R. H.; Ioannidou, Heraklidia A.; Elmarrouni, Abdelatif; Koch, Lizanne G.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 33 p. 8736 - 8741
Angew. Chem., 2013 , vol. 125, # 33 p. 8898 - 8904,7
反应条件
hydrogen; Rult;(R)-2,2'-bis(diphenylphosphino)-1,1'-binaphthylgt;(OCOCH3)2 in methanol T=15 - 30°C; P=76760.1 Torr; 12 h; Title compound not separated from byproducts;
参考文献
Valentine Jr.; Johnson; Priester; et al.
Journal of Organic Chemistry, 1980 , vol. 45, # 18 p. 3698 - 3703
反应条件
1: 82 percent / tributylphosphine / CH2Cl2 / 1.5 h / -20 °C 2: 86 percent / AIBN; Bu3SnH / benzene / 1.5 h / Heating View Scheme
参考文献
Hayes, Christopher J.; Pattenden, Gerald
Tetrahedron Letters, 1996 , vol. 37, # 2 p. 271 - 274
反应条件
potassium carbonate in acetone
参考文献
Campbell,R.V.M. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1975 , p. 897 - 913
参考文献
Sato, Tsueno; Otera, Junzo; Nozaki, Hitoshi
Tetrahedron Letters, 1989 , vol. 30, # 22 p. 2959 - 2962
